Catherine Duggan1, Jean de Dieu Tapsoba1, Frank Stanczyk2, Ching-Yun Wang1, Karen Foster Schubert3, Anne McTiernan1,3,4. 1. Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 2. Department of Obstetrics, Gynecology, and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. 3. School of Medicine, University of Washington, Seattle, WA. 4. Department of Epidemiology, University of Washington, Seattle, WA.
Abstract
OBJECTIVE: We tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obese women 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial. METHODS:From 2005 to 2008, 439 overweight/obese, postmenopausal women (BMI >25 kg/m), 50 to 75 years, were randomized to a year-long intervention: diet (reduced calorie, 10% weight loss, N = 118), exercise (225 min/wk moderate-to-vigorous activity, N = 117), combined diet + exercise (N = 117), or control (N = 87). At 12 months, 399 women provided blood; of these, 156 returned at 30 months and gave a blood sample. Hormones and SHBG were measured by immunoassay. Changes were compared using generalized estimating equations, adjusting for confounders. RESULTS: At 30 months, participants randomized to the diet + exercise intervention had statistically significant increases in SHBG levels versus controls (P = 0.001). There was no statistically significant change in SHBG in the exercise or diet intervention arms. Hormone levels did not vary by intervention arm from baseline to 30 months. Participants who maintained weight loss at 30 months had statistically significantly greater decreases in free estradiol and free testosterone (Ptrend = 0.02 and Ptrend = 0.04, respectively) and increases in SHBG (Ptrend < 0.0001) versus those who did not have sustained weight loss. Levels of other analytes did not vary by weight loss at 30 months. CONCLUSIONS:Sustained weight loss results in reductions in free estradiol and testosterone and increases in SHBG 18-month post-intervention.
RCT Entities:
OBJECTIVE: We tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obesewomen 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial. METHODS: From 2005 to 2008, 439 overweight/obese, postmenopausal women (BMI >25 kg/m), 50 to 75 years, were randomized to a year-long intervention: diet (reduced calorie, 10% weight loss, N = 118), exercise (225 min/wk moderate-to-vigorous activity, N = 117), combined diet + exercise (N = 117), or control (N = 87). At 12 months, 399 women provided blood; of these, 156 returned at 30 months and gave a blood sample. Hormones and SHBG were measured by immunoassay. Changes were compared using generalized estimating equations, adjusting for confounders. RESULTS: At 30 months, participants randomized to the diet + exercise intervention had statistically significant increases in SHBG levels versus controls (P = 0.001). There was no statistically significant change in SHBG in the exercise or diet intervention arms. Hormone levels did not vary by intervention arm from baseline to 30 months. Participants who maintained weight loss at 30 months had statistically significantly greater decreases in freeestradiol and freetestosterone (Ptrend = 0.02 and Ptrend = 0.04, respectively) and increases in SHBG (Ptrend < 0.0001) versus those who did not have sustained weight loss. Levels of other analytes did not vary by weight loss at 30 months. CONCLUSIONS:Sustained weight loss results in reductions in freeestradiol and testosterone and increases in SHBG 18-month post-intervention.
Authors: B E Ainsworth; W L Haskell; M C Whitt; M L Irwin; A M Swartz; S J Strath; W L O'Brien; D R Bassett; K H Schmitz; P O Emplaincourt; D R Jacobs; A S Leon Journal: Med Sci Sports Exerc Date: 2000-09 Impact factor: 5.411
Authors: R Kaaks; S Rinaldi; T J Key; F Berrino; P H M Peeters; C Biessy; L Dossus; A Lukanova; S Bingham; K-T Khaw; N E Allen; H B Bueno-de-Mesquita; C H van Gils; D Grobbee; H Boeing; P H Lahmann; G Nagel; J Chang-Claude; F Clavel-Chapelon; A Fournier; A Thiébaut; C A González; J R Quirós; M-J Tormo; E Ardanaz; P Amiano; V Krogh; D Palli; S Panico; R Tumino; P Vineis; A Trichopoulou; V Kalapothaki; D Trichopoulos; P Ferrari; T Norat; R Saracci; E Riboli Journal: Endocr Relat Cancer Date: 2005-12 Impact factor: 5.678
Authors: Karen E Foster-Schubert; Catherine M Alfano; Catherine R Duggan; Liren Xiao; Kristin L Campbell; Angela Kong; Carolyn E Bain; Ching-Yun Wang; George L Blackburn; Anne McTiernan Journal: Obesity (Silver Spring) Date: 2011-04-14 Impact factor: 5.002
Authors: Evelyn M Monninkhof; Miranda J Velthuis; Petra H M Peeters; Jos W R Twisk; Albertine J Schuit Journal: J Clin Oncol Date: 2009-08-17 Impact factor: 44.544
Authors: Jaana Lindström; Pirjo Ilanne-Parikka; Markku Peltonen; Sirkka Aunola; Johan G Eriksson; Katri Hemiö; Helena Hämäläinen; Pirjo Härkönen; Sirkka Keinänen-Kiukaanniemi; Mauri Laakso; Anne Louheranta; Marjo Mannelin; Merja Paturi; Jouko Sundvall; Timo T Valle; Matti Uusitupa; Jaakko Tuomilehto Journal: Lancet Date: 2006-11-11 Impact factor: 79.321
Authors: Donna H Ryan; Mark A Espeland; Gary D Foster; Steven M Haffner; Van S Hubbard; Karen C Johnson; Steven E Kahn; William C Knowler; Susan Z Yanovski Journal: Control Clin Trials Date: 2003-10
Authors: Xuehong Zhang; Shelley S Tworoger; A Heather Eliassen; Susan E Hankinson Journal: Breast Cancer Res Treat Date: 2013-01-03 Impact factor: 4.872
Authors: William C Knowler; Sarah E Fowler; Richard F Hamman; Costas A Christophi; Heather J Hoffman; Anne T Brenneman; Janet O Brown-Friday; Ronald Goldberg; Elizabeth Venditti; David M Nathan Journal: Lancet Date: 2009-10-29 Impact factor: 79.321
Authors: Sabina Rinaldi; Tim J Key; Petra H M Peeters; Petra H Lahmann; Annekatrin Lukanova; Laure Dossus; Carine Biessy; Paolo Vineis; Carlotta Sacerdote; Franco Berrino; Salvatore Panico; Rosario Tumino; Domenico Palli; Gabriele Nagel; Jakob Linseisen; Heiner Boeing; Andrew Roddam; Sheila Bingham; Kay-Tee Khaw; John Chloptios; Antonia Trichopoulou; Dimitrios Trichopoulos; Bertrand Tehard; Francoise Clavel-Chapelon; Carlos A Gonzalez; Nerea Larrañaga; Aurelio Barricarte; J Ramón Quirós; Maria-Dolores Chirlaque; Carmen Martinez; Evelyne Monninkhof; Diederick E Grobbee; H Bas Bueno-de-Mesquita; Pietro Ferrari; Nadia Slimani; Elio Riboli; Rudolf Kaaks Journal: Int J Cancer Date: 2006-06-01 Impact factor: 7.396
Authors: Mauro Lombardo; Marco Alfonso Perrone; Elena Guseva; Giovanni Aulisa; Elvira Padua; Chiara Bellia; David Della-Morte; Ferdinando Iellamo; Massimiliano Caprio; Alfonso Bellia Journal: Nutrients Date: 2020-08-17 Impact factor: 5.717
Authors: Aleksandra Biernacka-Bartnik; Piotr Kocełak; Aleksander Jerzy Owczarek; Piotr Choręza; Monika Puzianowska-Kuźnicka; Leszek Markuszewski; Paweł Madej; Jerzy Chudek; Magdalena Olszanecka-Glinianowicz Journal: Int J Endocrinol Date: 2022-01-31 Impact factor: 3.257
Authors: Leonardo Victor Galvão-Moreira; Anna Cyntia Brandão Nascimento; Izabella Mikaella Souza Campos D'Albuquerque; Marcus Antonio Silva Sousa; Haissa Oliveira Brito; Maria do Desterro Soares Brandão Nascimento; Maria Bethânia da Costa Chein; Luciane Maria Oliveira Brito Journal: PLoS One Date: 2019-09-11 Impact factor: 3.240