Marie Mathilde Bjerg Christensen1,2, Eva Elisabeth Hommel3, Marit Eika Jørgensen1,4,5, Bernt Johan von Scholten3, Jesper Fleischer6, Christian Stevns Hansen1. 1. 1 Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen , Gentofte, Denmark . 2. 2 Faculty of Health and Medical Science, University of Copenhagen , Copenhagen, Denmark . 3. 3 Steno Diabetes Center Copenhagen , Gentofte, Denmark . 4. 4 Department of Population Health and Morbidity, Health in Greenland, University of Southern Denmark , Odense, Denmark . 5. 6 Institute of Nursing and Health Science, University of Greenland, Nuuk, Greenland . 6. 5 Steno Diabetes Center Aarhus, Aarhus, Denmark .
Abstract
AIMS: The aim was to investigate the prevalence of diabetic sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in a Danish population of young adults with type 1 diabetes (T1D) using both established and novel measuring modalities. Furthermore, to investigate the association between continuous subcutaneous insulin infusion (CSII) treatment and these complications. MATERIALS AND METHODS: CAN was assessed by cardiovascular autonomic reflex tests. DSPN was assessed not only by perception of light touch and pain, vibration perception threshold (VPT), Brief Pain Inventory (BPI), and Michigan Neuropathy Screening Instrument questionnaires but also by novel modalities: electrochemical skin conductance (ESC), sural nerve conduction velocity (SNCV), and sural nerve amplitude potential (SNAP). RESULTS: The study comprised 156 young adults with a mean age of 22 years (standard deviation 1.6). The prevalence of CAN and early CAN was 9% and 28.1%, respectively. Subclinical DSPN was 55.1% and confirmed DSPN was 2.6%. Prevalence of abnormal SNAP was 23.8%, SNCV was 37.1%, ESC on the hands and feet was 4% and 8%, respectively, VPT was 1.3%, and BPI questionnaire was 1.9%. No association was found between CSII treatment and the measures of DSPN and CAN. CONCLUSION: DSPN and CAN are prevalent in young adults with T1D with no association found with CSII treatment. The use of novel measuring modalities identified a higher number of subjects with DSPN compared with established measures. Screening for diabetic neuropathy in young adults may be beneficial to detect and prevent nerve damages at early stages.
AIMS: The aim was to investigate the prevalence of diabetic sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in a Danish population of young adults with type 1 diabetes (T1D) using both established and novel measuring modalities. Furthermore, to investigate the association between continuous subcutaneous insulin infusion (CSII) treatment and these complications. MATERIALS AND METHODS: CAN was assessed by cardiovascular autonomic reflex tests. DSPN was assessed not only by perception of light touch and pain, vibration perception threshold (VPT), Brief Pain Inventory (BPI), and Michigan Neuropathy Screening Instrument questionnaires but also by novel modalities: electrochemical skin conductance (ESC), sural nerve conduction velocity (SNCV), and sural nerve amplitude potential (SNAP). RESULTS: The study comprised 156 young adults with a mean age of 22 years (standard deviation 1.6). The prevalence of CAN and early CAN was 9% and 28.1%, respectively. Subclinical DSPN was 55.1% and confirmed DSPN was 2.6%. Prevalence of abnormal SNAP was 23.8%, SNCV was 37.1%, ESC on the hands and feet was 4% and 8%, respectively, VPT was 1.3%, and BPI questionnaire was 1.9%. No association was found between CSII treatment and the measures of DSPN and CAN. CONCLUSION: DSPN and CAN are prevalent in young adults with T1D with no association found with CSII treatment. The use of novel measuring modalities identified a higher number of subjects with DSPN compared with established measures. Screening for diabetic neuropathy in young adults may be beneficial to detect and prevent nerve damages at early stages.
Authors: Elena Daskalaki; Anne Parkinson; Nicola Brew-Sam; Md Zakir Hossain; David O'Neal; Christopher J Nolan; Hanna Suominen Journal: J Med Internet Res Date: 2022-04-08 Impact factor: 7.076
Authors: Kara R Mizokami-Stout; Zoey Li; Nicole C Foster; Viral Shah; Grazia Aleppo; Janet B McGill; Richard Pratley; Elena Toschi; Lynn Ang; Rodica Pop-Busui Journal: Diabetes Care Date: 2020-02-06 Impact factor: 17.152
Authors: Marie Mathilde Bjerg Christensen; Eva Elisabeth Hommel; Marit Eika Jørgensen; Jesper Fleischer; Christian Stevns Hansen Journal: Front Endocrinol (Lausanne) Date: 2020-09-23 Impact factor: 5.555