Jia Li1, Ruijuan Liu2, Shifeng Tang2, Fubin Feng2, Cun Liu3, Lu Wang3, Wenge Zhao1, Tingting Zhang3, Yan Yao1, Xue Wang4, Changgang Sun5. 1. Weifang Medical University, Weifang, China. 2. Weifang Traditional Chinese Hospital, Weifang, China. 3. Shandong University of Traditional Chinese Medicine, Jinan, China. 4. Qingdao University, Qingdao, China. 5. Department of Oncology, Weifang Medical College Affiliated Hospital, No. 465, Yuhe Road, Kuiwen District, Weifang, ShanDong, China. scgdoctor@126.com.
Abstract
PURPOSE: The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer). METHODS: We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR). RESULTS: Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case-control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)]. CONCLUSIONS: Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.
PURPOSE: The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer). METHODS: We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle-Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR). RESULTS: Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case-control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)]. CONCLUSIONS:Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.
Authors: Essam R Othman; Ahmad Abo Markeb; Maha Y Khashbah; Ibrahim I Abdelaal; Tarek T ElMelegy; Ahmed N Fetih; Lisette E Van der Houwen; Cornelis B Lambalk; Velja Mijatovic Journal: Reprod Sci Date: 2020-11-20 Impact factor: 3.060
Authors: Dylan M Glubb; Tracy A O'Mara; Pik Fang Kho; Sally Mortlock; Peter A W Rogers; Dale R Nyholt; Grant W Montgomery; Amanda B Spurdle Journal: Hum Genet Date: 2021-07-15 Impact factor: 4.132