| Literature DB >> 30456755 |
Jung-Eun Kim1, Yoon-Jae Song2.
Abstract
Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for treatment of chronic myelogenous leukemia. In addition to antileukemic activity, HT and HHT are reported to possess potent antiviral activity. In this study, we investigated the effects of HT and HHT on replication of varicella-zoster virus (VZV) in vitro. HT and HHT, but not their biologically inactive parental alkaloid cephalotaxine (CET), significantly inhibited replication of recombinant VZV-pOka luciferase. Furthermore, HT and HHT, but not CET, strongly induced down-regulation of VZV lytic genes and exerted potent antiviral effects against a VZV clinical isolate. The collective data support the utility of HT and HHT as effective antiviral candidates for treatment of VZV-associated diseases.Entities:
Keywords: antiviral; harringtonine; homoharringtonine; varicella zoster virus
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Year: 2018 PMID： 30456755 PMCID： PMC7090801 DOI： 10.1007/s12275-019-8514-z
Source DB: PubMed Journal: J Microbiol ISSN： 1225-8873 Impact factor: 3.422