Yuanyuan Li1, Weifeng Shang2, Qiaofa Lu1, Bo Zhang1, Yali Ren3, Yanbo Sun4, Junwu Dong5. 1. Department of Respiratory Medicine, Wuhan Forth Hospital; Puai Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China. 2. Department of Nephrology and Rheumatology, Wuhan Forth Hospital; Puai Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China. 3. Department of Medical Affaires, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China. 4. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China. sunyanbo12@163.com. 5. Department of Nephrology and Rheumatology, Wuhan Forth Hospital; Puai Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China. junwudongwuhan@163.com.
Abstract
PURPOSE: Recent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD. METHODS: PubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. We also performed sensitivity analyses and assessments of publishing bias. RESULTS: Fourteen observational studies (n = 1483 participants) were included in this meta-analysis. The result of analysis in random-effect model showed that the pooled prevalence was 21% (95% CI 16-28), with significant heterogeneity between these studies (I2 = 84%, p < 0.01). Sensitivity analysis further demonstrated the results to be robust. Besides, the Egger's test (p = 0.287) showed no significant publication bias. CONCLUSIONS: PH is highly prevalent in patients with PD. Further studies are encouraged to definitively clarify the relationship between PH and PD.
PURPOSE: Recent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD. METHODS: PubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. We also performed sensitivity analyses and assessments of publishing bias. RESULTS: Fourteen observational studies (n = 1483 participants) were included in this meta-analysis. The result of analysis in random-effect model showed that the pooled prevalence was 21% (95% CI 16-28), with significant heterogeneity between these studies (I2 = 84%, p < 0.01). Sensitivity analysis further demonstrated the results to be robust. Besides, the Egger's test (p = 0.287) showed no significant publication bias. CONCLUSIONS: PH is highly prevalent in patients with PD. Further studies are encouraged to definitively clarify the relationship between PH and PD.
Authors: S S Bozbas; S Akcay; C Altin; H Bozbas; E Karacaglar; S Kanyilmaz; B Sayin; H Muderrisoglu; M Haberal Journal: Transplant Proc Date: 2009-09 Impact factor: 1.066
Authors: Lalathaksha Kumbar; Paul A Fein; Muhammad A Rafiq; Cezary Borawski; Jyotiprakas Chattopadhyay; Morrell M Avram Journal: Adv Perit Dial Date: 2007