Literature DB >> 30455245

Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model.

Sebastian Wurster1, Russell E Lewis2, Nathaniel D Albert1, Dimitrios P Kontoyiannis3.   

Abstract

Breakthrough mucormycosis in patients receiving isavuconazole prophylaxis or therapy has been reported. We compared the impact of isavuconazole and voriconazole exposure on the virulence of clinical isolates of Aspergillus fumigatus and different Mucorales species in a Drosophila melanogaster infection model. In contrast to A. fumigatus, a hypervirulent phenotype was found in all tested Mucorales upon preexposure to either voriconazole or isavuconazole. These findings may contribute to the explanation of breakthrough mucormycosis in isavuconazole-treated patients.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Aspergillus fumigatus; Drosophila melanogaster; Rhizopus arrhizus; isavuconazole

Mesh：

Substances：

Year:  2019        PMID： 30455245      PMCID： PMC6355575          DOI： 10.1128/AAC.01896-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

Review 1.  Epidemiology and outcome of zygomycosis: a review of 929 reported cases.

Authors:  Maureen M Roden; Theoklis E Zaoutis; Wendy L Buchanan; Tena A Knudsen; Tatyana A Sarkisova; Robert L Schaufele; Michael Sein; Tin Sein; Christine C Chiou; Jaclyn H Chu; Dimitrios P Kontoyiannis; Thomas J Walsh
Journal:  Clin Infect Dis       Date:  2005-07-29       Impact factor: 9.079

2.  Real-Life Use of Isavuconazole in Patients Intolerant to Other Azoles.

Authors:  Eloy E Ordaya; George J Alangaden
Journal:  Clin Infect Dis       Date:  2016-08-23       Impact factor: 9.079

Review 3.  Epidemiology and clinical manifestations of mucormycosis.

Authors:  George Petrikkos; Anna Skiada; Olivier Lortholary; Emmanuel Roilides; Thomas J Walsh; Dimitrios P Kontoyiannis
Journal:  Clin Infect Dis       Date:  2012-02       Impact factor: 9.079

4.  Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae.

Authors:  Anne-Pauline Bellanger; Nathaniel D Albert; Russell E Lewis; Thomas J Walsh; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2015-09-21       Impact factor: 5.191

5.  Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases.

Authors:  Dimitrios P Kontoyiannis; Michail S Lionakis; Russell E Lewis; Georgios Chamilos; Mimi Healy; Cheryl Perego; Amar Safdar; Hagop Kantarjian; Richard Champlin; Thomas J Walsh; Issam I Raad
Journal:  J Infect Dis       Date:  2005-03-16       Impact factor: 5.226

6.  Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection.

Authors:  Russell E Lewis; Guangling Liao; Weiqun Wang; Randall A Prince; Dimitrios P Kontoyiannis
Journal:  Virulence       Date:  2011-07-01       Impact factor: 5.882

7.  Increased virulence of Zygomycetes organisms following exposure to voriconazole: a study involving fly and murine models of zygomycosis.

Authors:  Gregory A Lamaris; Ronen Ben-Ami; Russell E Lewis; Georgios Chamilos; George Samonis; Dimitrios P Kontoyiannis
Journal:  J Infect Dis       Date:  2009-05-01       Impact factor: 5.226

8.  Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis.

Authors:  Georgios Chamilos; Russell E Lewis; Jianhua Hu; Lianchun Xiao; Tomasz Zal; Michel Gilliet; Georg Halder; Dimitrios P Kontoyiannis
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-26       Impact factor: 11.205

Review 9.  Voriconazole-associated zygomycosis: a significant consequence of evolving antifungal prophylaxis and immunosuppression practices?

Authors:  G N Pongas; R E Lewis; G Samonis; D P Kontoyiannis
Journal:  Clin Microbiol Infect       Date:  2009-10       Impact factor: 8.067

10.  Breakthrough Fungal Infections in Patients With Leukemia Receiving Isavuconazole.

Authors:  Caitlin R Rausch; Adam J DiPippo; Prithviraj Bose; Dimitrios P Kontoyiannis
Journal:  Clin Infect Dis       Date:  2018-10-30       Impact factor: 9.079
  10 in total
  5 in total

1.  Triazole Priming as an Adaptive Response and Gateway to Resistance in Aspergillus fumigatus.

Authors:  Ety Harish; Argha Sarkar; Mariana Handelman; Amar Abo Kandil; Yana Shadkchan; Sebastian Wurster; Dimitrios P Kontoyiannis; Nir Osherov
Journal:  Antimicrob Agents Chemother       Date:  2022-07-20       Impact factor: 5.938

Review 2.  Fungal Priming: Prepare or Perish.

Authors:  Ety Harish; Nir Osherov
Journal:  J Fungi (Basel)       Date:  2022-04-25

3.  Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus.

Authors:  Zhonghua Liu; Shriya Raj; Norman van Rhijn; Marcin Fraczek; Jean-Philippe Michel; Odile Sismeiro; Rachel Legendre; Hugo Varet; Thierry Fontaine; Michael Bromley; Jean-Paul Latgé
Journal:  mBio       Date:  2021-05-18       Impact factor: 7.867

4.  Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds.

Authors:  Sebastian Wurster; Alexander M Tatara; Nathaniel D Albert; Ashraf S Ibrahim; Joseph Heitman; Soo Chan Lee; Amol C Shetty; Carrie McCracken; Karen T Graf; Antonios G Mikos; Vincent M Bruno; Dimitrios P Kontoyiannis
Journal:  mBio       Date:  2020-06-30       Impact factor: 7.867

5.  Breakthrough Mucormycosis Developing on Mucorales-Active Antifungals Portrays a Poor Prognosis in Patients with Hematologic Cancer.

Authors:  Dierdre B Axell-House; Sebastian Wurster; Ying Jiang; Andreas Kyvernitakis; Russell E Lewis; Jeffrey J Tarrand; Issam I Raad; Dimitrios P Kontoyiannis
Journal:  J Fungi (Basel)       Date:  2021-03-17
  5 in total

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