Literature DB >> 30455235

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.

George R Thompson1,2, Charles R Krois3, Verena K Affolter4, Angela D Everett5, E Katarina Varjonen5, Victoria R Sharon6, Anil Singapuri7, Michael Dennis7, Ian McHardy7, Hong Sik Yoo3, Dawn M Fedor3, Nathan P Wiederhold8, Phylicia A Aaron9, Angie Gelli9, Joseph L Napoli3, Stephen D White5.   

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  alopecia; antifungal; fluconazole; side effect

Mesh：

Substances：

Year:  2019        PMID： 30455235      PMCID： PMC6355562          DOI： 10.1128/AAC.01384-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Alopecia associated with fluconazole therapy.

Authors:  N H Shear
Journal:  Ann Intern Med       Date:  1996-07-15       Impact factor: 25.391

2.  Binding of steroid hormones by the 105,00 x g supernatant fraction from homogenates of rat skin and variations during the hair cycle.

Authors:  U Eppenberger; S L Hsia
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

3.  Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla.

Authors:  Kerstin Foitzik; Tanja Spexard; Motonobu Nakamura; Ursula Halsner; Ralf Paus
Journal:  J Invest Dermatol       Date:  2005-06       Impact factor: 8.551

4.  Hair pull test: Evidence-based update and revision of guidelines.

Authors:  Katherine A McDonald; Amanda J Shelley; Sophia Colantonio; Jennifer Beecker
Journal:  J Am Acad Dermatol       Date:  2016-12-20       Impact factor: 11.527

5.  Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.

Authors:  Ariel R Topletz; Jayne E Thatcher; Alex Zelter; Justin D Lutz; Suzanne Tay; Wendel L Nelson; Nina Isoherranen
Journal:  Biochem Pharmacol       Date:  2011-10-14       Impact factor: 5.858

6.  Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase.

Authors:  Jayne E Thatcher; Brian Buttrick; Scott A Shaffer; Jakob A Shimshoni; David R Goodlett; Wendel L Nelson; Nina Isoherranen
Journal:  Mol Pharmacol       Date:  2011-04-26       Impact factor: 4.436

7.  Phase I evaluation of all-trans retinoic acid with and without ketoconazole in adults with solid tumors.

Authors:  J S Lee; R A Newman; S M Lippman; F V Fossella; M Calayag; M N Raber; I H Krakoff; W K Hong
Journal:  J Clin Oncol       Date:  1995-06       Impact factor: 44.544

8.  Fluconazole alters CYP26 gene expression in mouse embryos.

Authors:  Gian Mario Tiboni; Francesca Marotta; Erminia Carletti
Journal:  Reprod Toxicol       Date:  2009-01-21       Impact factor: 3.143

9.  Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo.

Authors:  Yuanping Wang; Reza Zolfaghari; A Catharine Ross
Journal:  Arch Biochem Biophys       Date:  2002-05-15       Impact factor: 4.013

10.  Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity.

Authors:  Dong Sik Jung; Frank P Tverdek; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2014-09-08       Impact factor: 5.191
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  1 in total

1.  Experience of Isavuconazole as a Salvage Therapy in Chronic Pulmonary Fungal Disease.

Authors:  Lisa Nwankwo; Desmond Gilmartin; Sheila Matharu; Ali Nuh; Jackie Donovan; Darius Armstrong-James; Anand Shah
Journal:  J Fungi (Basel)       Date:  2022-03-31
  1 in total

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