Literature DB >> 30455203

DNA Damage Response Gene Alterations in Urothelial Cancer: Ready for Practice?

Petros Grivas1,2.   

Abstract

Cisplatin-based neoadjuvant chemotherapy prior to radical cystectomy is standard in fit patients. Inactivating mutations of the nucleotide excision repair gene ERCC2 can predict response to cisplatin-based chemotherapy. Evaluation of the functional impact of ERCC2 mutations can provide mechanistic frameworks supporting the potential predictive role of ERCC2 loss of function.See related article by Li et al., p. 977. ©2018 American Association for Cancer Research.

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Year:  2018        PMID： 30455203     DOI： 10.1158/1078-0432.CCR-18-2512

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  4 in total

Review 1.  Role of Targeted Therapies in Management of Metastatic Urothelial Cancer in the Era of Immunotherapy.

Authors:  Petros Grivas; Evan Y Yu
Journal:  Curr Treat Options Oncol       Date:  2019-06-28

2.  A Preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer.

Authors:  Dongbo Xu; Qiang Cao; Li Wang; Jianmin Wang; Bo Xu; Kristopher Attwood; Lei Wei; Yue Wu; Gary J Smith; Eriko Katsuta; Kazuaki Takabe; Gurkamal Chatta; Khurshid A Guru; David W Goodrich; Qiang J Li
Journal:  Mol Cancer Ther       Date:  2022-05-04       Impact factor: 6.009

Review 3.  Bladder preservation: Translating discovery for clinical impact in urothelial cancer.

Authors:  David T Miyamoto; Philip H Abbosh; Catharine M L West; Kent W Mouw
Journal:  Urol Oncol       Date:  2020-11-28       Impact factor: 2.954

4.  Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer.

Authors:  Judit Börcsök; Zsofia Sztupinszki; Raie Bekele; Sizhi P Gao; Miklos Diossy; Amruta S Samant; Kasia M Dillon; Viktoria Tisza; Sándor Spisák; Orsolya Rusz; Istvan Csabai; Helle Pappot; Zoë J Frazier; David J Konieczkowski; David Liu; Naresh Vasani; James A Rodrigues; David B Solit; Jean H Hoffman-Censits; Elizabeth R Plimack; Jonathan E Rosenberg; Jean-Bernard Lazaro; Mary-Ellen Taplin; Gopa Iyer; Søren Brunak; Rita Lozsa; Eliezer M Van Allen; Dávid Szüts; Kent W Mouw; Zoltan Szallasi
Journal:  Clin Cancer Res       Date:  2020-11-18       Impact factor: 13.801
  4 in total

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