Murtadha Al-Khabori1, Shahina Daar2,3, Said A Al-Busafi4, Humoud Al-Dhuhli5, AlGhalya A Alumairi6, Moez Hassan1, Sara Al-Rahbi7, Umaima Al-Ajmi5. 1. a Department of Haemtology , Sultan Qaboos University Hospital, Sultan Qaboos University , Muscat , Oman. 2. b Department of Haemtology , College of Medicine & Health Sciences Sultan Qaboos University , Muscat , Oman. 3. c Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University , Stellenbosch , South Africa. 4. d Gastroenterology and Hepatology Unit Department of Medicine , Sultan Qaboos University Hospital Sultan Qaboos University , Muscat , Oman. 5. e Department of Radiology and Molecular Imaging , Sultan Qaboos University Hospital Sultan Qaboos University , Muscat , Oman. 6. f Internal Medicine Program , Oman Medical Specialty Board , Muscat , Oman. 7. g Nursing , Sultan Qaboos University Hospital , Muscat , Oman.
Abstract
OBJECTIVES: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). METHODS: All patients with TM over the age of 10 years were included in the study. RESULTS: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p = .0373). Additionally, the 5yrSF (p = .00661), the LIC (p = .0225) and the lowest LIC of the previous 5 years (p = .0211) were significant. In the multivariable logistic regression model, only 5yrSF (p = .0035) and gender (p = .00984) remained significant. CONCLUSIONS: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.
OBJECTIVES: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). METHODS: All patients with TM over the age of 10 years were included in the study. RESULTS: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p = .0373). Additionally, the 5yrSF (p = .00661), the LIC (p = .0225) and the lowest LIC of the previous 5 years (p = .0211) were significant. In the multivariable logistic regression model, only 5yrSF (p = .0035) and gender (p = .00984) remained significant. CONCLUSIONS: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.
Authors: Mohammad S Sargolzaei; Milad G Shirsavar; Jasem Allahyari; Ali Bazi; Abolghasem P Nasirabady Journal: Sultan Qaboos Univ Med J Date: 2022-08-25