Literature DB >> 30453219

LC-MS-guided isolation of anti-inflammatory 2-(2-phenylethyl)chromone dimers from Chinese agarwood (Aquilaria sinensis).

Hui-Xia Huo1, Yu-Fan Gu1, Zhi-Xiang Zhu1, Yun-Feng Zhang1, Xiao-Nan Chen1, Peng-Wei Guan1, She-Po Shi1, Yue-Lin Song1, Yun-Fang Zhao1, Peng-Fei Tu2, Jun Li3.   

Abstract

Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values in the range 0.6-37.1 μM.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  2-(2-Phenylethyl)chromone dimer; Anti-inflammatory activity; Aquilaria sinensis (Lour.) Spreng; Aquisinenone; Chinese agarwood

Mesh：

Substances：

Year:  2018        PMID： 30453219     DOI： 10.1016/j.phytochem.2018.11.003

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  5 in total

1.  Phytochemical Constituents of Aquilaria malaccensis Leaf Extract and Their Anti-Inflammatory Activity against LPS/IFN-γ-Stimulated RAW 264.7 Cell Line.

Authors:  Manar A Eissa; Yumi Z H-Y Hashim; Saripah S S Abdul Azziz; Hamzah Mohd Salleh; Muhammad Lokman Md Isa; Nor Malia Abd Warif; Fauziah Abdullah; Eman Ramadan; Dina M El-Kersh
Journal:  ACS Omega       Date:  2022-04-26

Review 2.  Rediscovering the Therapeutic Potential of Agarwood in the Management of Chronic Inflammatory Diseases.

Authors:  Juman Mohammed Rasmi Alamil; Keshav Raj Paudel; Yinghan Chan; Dikaia Xenaki; Jithendra Panneerselvam; Sachin Kumar Singh; Monica Gulati; Niraj Kumar Jha; Deepak Kumar; Parteek Prasher; Gaurav Gupta; Raniya Malik; Brian George Oliver; Philip Michael Hansbro; Kamal Dua; Dinesh Kumar Chellappan
Journal:  Molecules       Date:  2022-05-09       Impact factor: 4.927

3.  UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis.

Authors:  Tongdong Kuang; Hui-Qin Chen; Hao Wang; Fan-Dong Kong; Cai-Hong Cai; Wen-Hua Dong; Jing-Zhe Yuan; Wen-Li Mei; Hao-Fu Dai
Journal:  RSC Adv       Date:  2019-05-31       Impact factor: 4.036

4.  Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.

Authors:  Xiao-Hui Wang; Bo-Wen Gao; Yu Nakashima; Takahiro Mori; Zhong-Xiu Zhang; Takeshi Kodama; Yuan-E Lee; Ze-Kun Zhang; Chin-Piow Wong; Qian-Qian Liu; Bo-Wen Qi; Juan Wang; Jun Li; Xiao Liu; Ikuro Abe; Hiroyuki Morita; Peng-Fei Tu; She-Po Shi
Journal:  Nat Commun       Date:  2022-01-17       Impact factor: 14.919

5.  Solvent-dependent regio- and stereo-selective reactions of 3-formylchromones with 2-aminobenzothiazoles and transacetalization efficiency of the product 3-((benzo[d]thiazol-2-ylimino)butyl)-4H-chromen-4-one.

Authors:  Owais Ahmed; Vandana Cherkadu; Praveen Kumar Kalavagunta; Jing Shang
Journal:  RSC Adv       Date:  2019-07-02       Impact factor: 3.361
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.