| Literature DB >> 30452759 |
Jun Yasuda1, Kengo Kinoshita1,2,3, Fumiki Katsuoka1, Inaho Danjoh1, Mika Sakurai-Yageta1, Ikuko N Motoike1, Yoko Kuroki1, Sakae Saito1, Kaname Kojima1, Matsuyuki Shirota1,4, Daisuke Saigusa1, Akihito Otsuki1, Junko Kawashima1, Yumi Yamaguchi-Kabata1, Shu Tadaka1, Yuichi Aoki1, Takahiro Mimori1, Kazuki Kumada1, Jin Inoue1, Satoshi Makino1, Miho Kuriki1, Nobuo Fuse1, Seizo Koshiba1, Osamu Tanabe1, Masao Nagasaki1, Gen Tamiya1, Ritsuko Shimizu1,5, Takako Takai-Igarashi1, Soichi Ogishima1, Atsushi Hozawa1, Shinichi Kuriyama1,6, Junichi Sugawara1, Akito Tsuboi1, Hideyasu Kiyomoto1, Tadashi Ishii1,7, Hiroaki Tomita1,6, Naoko Minegishi1, Yoichi Suzuki1, Kichiya Suzuki1, Hiroshi Kawame1, Hiroshi Tanaka1,8, Yasuyuki Taki1,3, Nobuo Yaegashi1,9, Shigeo Kure1,10, Fuji Nagami1, Kenjiro Kosaki11, Yoichi Sutoh12, Tsuyoshi Hachiya12, Atsushi Shimizu12, Makoto Sasaki12,13, Masayuki Yamamoto1,14.
Abstract
Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, medical genetics and prospective cohort studies to develop a critical infrastructure for the establishment of PHC. To date, a TMM CommCohort (adult general population) and a TMM BirThree Cohort (birth+three-generation families) have conducted recruitments and baseline surveys. Genome analyses as part of the TMM Project will aid in the development of a high-fidelity whole-genome Japanese reference panel, in designing custom single-nucleotide polymorphism (SNP) arrays specific to Japanese, and in estimation of the biological significance of genetic variations through linked investigations of the cohorts. Whole-genome sequencing from >3,500 unrelated Japanese and establishment of a Japanese reference genome sequence from long-read data have been done. We next aim to obtain genotype data for all TMM cohort participants (>150,000) using our custom SNP arrays. These data will help identify disease-associated genomic signatures in the Japanese population, while genomic data from TMM BirThree Cohort participants will be used to improve the reference genome panel. Follow-up of the cohort participants will allow us to test the genetic markers and, consequently, contribute to the realization of PHC.Entities:
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Year: 2019 PMID： 30452759 DOI： 10.1093/jb/mvy096
Source DB: PubMed Journal: J Biochem ISSN： 0021-924X Impact factor: 3.387