Sang Bae Lee1, Yu-Sik Kim2, Jung Hye Kim1, Kahui Park1, Ji Sun Nam1,2, Shinae Kang1,2, Jong Suk Park1,2, Sehyun Shin3, Chul Woo Ahn1,2. 1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. 2. Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea. 3. Department of Engineering, Korea University College of Medicine, Seoul, South Korea.
Abstract
BACKGROUND AND OBJECTIVE: Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN). METHODS: 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Hemorheologic parameters, including erythrocyte sedimentation rate (ESR), elongation index at 3 Pa (EI) were measured using microfluidic hemorheometer. Various metabolic parameters were measured from fasting blood samples. The subjects were stratified into three groups according to classification of DN by urinary albumin to creatinine ratio (ACR) and four groups by estimated glomerular filtration rate (GFR), than analyzed. RESULTS: Significant differences were observed in metabolic and hemorheologic parameters according to progression of DN. Among them, (Fibrinogen×ESR)/ EI differed in all three groups of urinary ACR. In multiple regression analysis, (Fibrinogen×ESR)/ EI was an independent predictor of urine ACR after adjusted with confounding factors (ß = 0.010, p < 0.001). (Fibrinogen×ESR)/ EI also showed significant difference no or minimal CKD stage, moderate CKD and severe CKD classified by GFR. This parameter showed area under curve (AUC) of the receiver operating characteristic (ROC) curve of 0.762, and moderate sensitivity and specificity to predict prevalence of microalbuminuria. CONCLUSIONS: (Fibrinogen×ESR)/ EI is a sensitive parameter for screening diabetic nephropathy.
BACKGROUND AND OBJECTIVE: Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN). METHODS: 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Hemorheologic parameters, including erythrocyte sedimentation rate (ESR), elongation index at 3 Pa (EI) were measured using microfluidic hemorheometer. Various metabolic parameters were measured from fasting blood samples. The subjects were stratified into three groups according to classification of DN by urinary albumin to creatinine ratio (ACR) and four groups by estimated glomerular filtration rate (GFR), than analyzed. RESULTS: Significant differences were observed in metabolic and hemorheologic parameters according to progression of DN. Among them, (Fibrinogen×ESR)/ EI differed in all three groups of urinary ACR. In multiple regression analysis, (Fibrinogen×ESR)/ EI was an independent predictor of urine ACR after adjusted with confounding factors (ß = 0.010, p < 0.001). (Fibrinogen×ESR)/ EI also showed significant difference no or minimal CKD stage, moderate CKD and severe CKD classified by GFR. This parameter showed area under curve (AUC) of the receiver operating characteristic (ROC) curve of 0.762, and moderate sensitivity and specificity to predict prevalence of microalbuminuria. CONCLUSIONS: (Fibrinogen×ESR)/ EI is a sensitive parameter for screening diabetic nephropathy.
Authors: A V Sidekhmenova; O I Aliev; N S Domnina; P S Vlasov; E V Popova; M B Plotnikov Journal: Bull Exp Biol Med Date: 2022-02-17 Impact factor: 0.804
Authors: Il Rae Park; Jimi Choi; Eun Young Ha; Seung Min Chung; Jun Sung Moon; Sehyun Shin; Sin Gon Kim; Kyu Chang Won Journal: Clin Hemorheol Microcirc Date: 2022 Impact factor: 2.411
Authors: Juan F Rivelli Antonelli; Verónica S Santander; Ayelen D Nigra; Noelia E Monesterolo; Gabriela Previtali; Emilianao Primo; Lisandro H Otero; César H Casale Journal: J Physiol Biochem Date: 2021-06-07 Impact factor: 4.158