Min Yang1, Meizhen Tan2, Jieling Wu3, Zhuojie Chen4, Xiaoling Long5, Yongmei Zeng6, Huabo Cai7, Yong Zhang8, Lanlan Geng1, Yulian Xiao2, Haijin Ke9, Ying Liu3, Linhui Rong10, Simao Fu5, Hong Wang11, Yuan Wang12, Xiaoxiu Li13, Peiyu Chen1, Kelvin Li14, Jing Xie1, Huan Chen1, Huiwen Li1, Hongli Wang1, Ding-You Li15, Sitang Gong1. 1. Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China. 2. Department of Healthcare, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China. 3. Department of Healthcare, Guangdong Women and Children Hospital, Guangzhou, China. 4. Department of Pediatrics, Jiangmen Maternity and Child Health Care Hospital, Jiangmen, China. 5. Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China. 6. Department of Pediatrics, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China. 7. Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen, China. 8. Department of Clinical Nutrition and Healthcare, Dongguan Maternal and Child Health Care Hospital, Dongguan, China. 9. Department of Healthcare, Panyu Campus, Guangdong Women and Children Hospital, Guangzhou, China. 10. Department of Healthcare, Jiangmen Maternity and Child Health Care Hospital, Jiangmen, China. 11. Department of Healthcare, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China. 12. Department of Healthcare, Shenzhen Children's Hospital, Shenzhen, China. 13. Department of Gastroenterology, Dongguan Maternal and Child Health Care Hospital, Dongguan, China. 14. Department of Global Biostatistics and Data Science, Center for Bioinformatics and Genomics, Tulane University, New Orleans, Louisiana, USA. 15. Division of Gastroenterology, Children's Mercy Hospital, Kansas City, Missouri, USA.
Abstract
BACKGROUND: Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. METHODS: We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA. RESULTS: A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP. CONCLUSIONS: The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP.
BACKGROUND:Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. METHODS: We carried out a prospective survey in 7 participating hospitals throughout southern China. We included infants ≤12 months of age during the survey. For those suspected of CMPA, oral food challenge with cow's milk protein (CMP) was performed. A follow-up telephone interview was conducted at 12 months after the diagnosis to assess the clinical outcome of CMPA. RESULTS: A total of 9910 questionnaire surveys were distributed and 7364 (74.3%) were returned. The eligible survey number of surveys was 6768 (91.9%). A total of 182 infants was confirmed with CMPA, including 13 with anaphylactic reactions, 28 with clinical symptoms and serum immunoglobulin E (sIgE) >3.5 IU/mL, and 141 with positive CMP challenge test. The prevalence of CMPA was 2.69%. Infants with confirmed CMPA had significantly stronger family history of either 1 or both parents with food allergy, higher Cesarean section rate, and lower rate of breastfeeding, compared with those without CMPA. At 12-month telephone follow-up of 176 CMPA infants, 136 infants (77.3%) had become tolerant to CMP. CONCLUSIONS: The prevalence of CMPA was 2.69%. CMPA infants had a strong family history of food allergy and atopy. Both Cesarean delivery and formula feeding were risk factors for CMPA. At 12-month follow-up, the majority of CMPA infants had become tolerant to CMP.
Authors: Yvan Vandenplas; Christophe Dupont; Philippe Eigenmann; Ralf G Heine; Arne Høst; Anette Järvi; Mikael Kuitunen; Rajat Mukherjee; Carmen Ribes-Koninckx; Hania Szajewska; Andrea von Berg; Zheng-Yan Zhao Journal: Pediatr Gastroenterol Hepatol Nutr Date: 2021-07-05