Mehdi Ariana1, Majid Pornour2, Saeedeh Sarafraz Mehr1, Hajar Vaseghi2, Shahla Mohammad Ganji3, Mohammad R Alivand4, Maryam Salari5, Mohammad E Akbari1. 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Photo Healing & Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture & Research (ACECR), Tehran, Iran. 3. National Institute of Genetic Engineering & Biotechnology (NIGEB), Tehran, Iran. 4. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. 5. Department of Biostatistics, Faculty of Medical Sciences, Terabit Modares University, Tehran, Iran.
Abstract
AIM: Modifications of oxytocin (OT) concentration and OT receptor (OXTR) expression level have different effects on breast cancer-derived cells. This study was conducted to evaluate OT variation in breast cancer patients and to evaluate OXTR expression changes in breast cancer tissues. METHODS: The plasma concentrations of OT in both breast cancer patients and healthy individuals' samples were assessed. OXTR variations were then assessed in both cancerous and noncancerous breast tissues. RESULTS: OT had an increase in breast cancer patients and expression of OXTR in contralateral breast was more than cancerous tissues. CONCLUSION: Despite the high levels of OT concentration in breast cancer patients, it seems that a lower expression of OXTR in cancerous tissues can be effective in the breast cancer progression.
AIM: Modifications of oxytocin (OT) concentration and OT receptor (OXTR) expression level have different effects on breast cancer-derived cells. This study was conducted to evaluate OT variation in breast cancerpatients and to evaluate OXTR expression changes in breast cancer tissues. METHODS: The plasma concentrations of OT in both breast cancerpatients and healthy individuals' samples were assessed. OXTR variations were then assessed in both cancerous and noncancerous breast tissues. RESULTS:OT had an increase in breast cancerpatients and expression of OXTR in contralateral breast was more than cancerous tissues. CONCLUSION: Despite the high levels of OT concentration in breast cancerpatients, it seems that a lower expression of OXTR in cancerous tissues can be effective in the breast cancer progression.
Entities:
Keywords:
breast cancer; gene expression; oxytocin; oxytocin receptor
Authors: Farhad Seif; Hajar Vaseghi; Mehdi Ariana; Shahla Mohammad Ganji; Mohammad Nazari; Kowsar Kiani Rad; Majid Pornour Journal: Eur J Breast Health Date: 2022-04-01