| Literature DB >> 30451362 |
Farzad Zamani1, Rasool Babaahmadi2, Brian F Yates2, Michael G Gardiner2, Alireza Ariafard2, Stephen G Pyne1, Christopher J T Hyland1.
Abstract
A synthesis of unconjugated (E)-enediynes from allenyl amino alcohols is reported and their gold-catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual-gold σ,π-activation mode, involving a key gold-vinylidene- and allenyl-gold-containing intermediate.Entities:
Keywords: cycloaromatization; dual-gold catalysis; enediynes; isoindolinones
Year: 2019 PMID： 30451362 DOI： 10.1002/anie.201810794
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336