Literature DB >> 3045068

Inhibition of adherence of Candida albicans by conventional and experimental antifungal drugs.

V Vuddhakul1, J G McCormack, W K Seow, S E Smith, Y H Thong.   

Abstract

We tested the effects of antifungal drugs on adherence of Candida albicans in vitro. Significant reduction of adherence occurred after 2 h incubation with amphotericin B, nystatin, miconazole, econazole, ketoconazole, chlorohexidine and ICI 195,739. Significant inhibition of candida adherence by 5-fluorocytosine and amorolfin required 18 h incubation. Combinations of amphotericin B with 5-fluorocytosine, miconazole, ICI 195,739 and amorolfin resulted in synergistic inhibition of adherence. Adherence is an important pathogenic mechanism in candida infections and interference with this process may represent a major component of the mode of action of antifungal drugs.

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Year:  1988        PMID： 3045068     DOI： 10.1093/jac/21.6.755

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  5 in total

1.  Do microorganisms play a role in irradiation mucositis?

Authors:  H K van Saene; M V Martin
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-12       Impact factor: 3.267

Review 2.  Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections.

Authors:  M Haria; H M Bryson
Journal:  Drugs       Date:  1995-01       Impact factor: 9.546

3.  Inhibition of adherence of mucoid Pseudomonas aeruginosa by alginase, specific monoclonal antibodies, and antibiotics.

Authors:  G T Mai; J G McCormack; W K Seow; G B Pier; L A Jackson; Y H Thong
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

4.  Diagnostic potential of IgA coated Candida cells in mucous membrane candidiasis.

Authors:  L Polonelli; S Conti; M G Menozzi; M Gerloni; R Elosegui; M Fernandez; M Alvarez; J Ponton
Journal:  Mycopathologia       Date:  1991-11       Impact factor: 2.574

5.  Modulation of interactions of Candida albicans and endothelial cells by fluconazole and amphotericin B.

Authors:  M A Ghannoum; S G Filler; A S Ibrahim; Y Fu; J E Edwards
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191
  5 in total

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