Max T Aung1, Kelly K Ferguson2, David E Cantonwine3, Thomas F McElrath3, John D Meeker4. 1. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States. 2. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. 3. Division of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. 4. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: meekerj@umich.edu.
Abstract
INTRODUCTION: Preterm birth continues to be a significant public heath concern and is a leading cause of perinatal and infant mortality. Environmental exposures to phenols and parabens are suspected to potentially contribute to the pathology of preterm birth, yet limited human studies have characterized the extent to which these toxicants are associated with birth outcomes. METHODS: We examined the associations between phenols, parabens, and preterm birth, within pregnant women who were recruited early in gestation into the LIFECODES cohort at Brigham and Women's Hospital in Boston, Massachusetts. Urine samples were collected at up to 4 time points in pregnancy and analyzed for phenols and parabens. We selected 130 cases of preterm birth (defined as delivery before 37 weeks gestation), and 350 random controls. We categorized preterm birth subtypes based on clinical presentation and identified 75 cases of spontaneous preterm birth (characterized by spontaneous preterm labor and/or preterm premature rupture of membranes), and 37 cases of placental preterm birth (characterized by preeclampsia and/or intrauterine growth restriction). We used multivariate logistic regression with visit specific and geometric averages of phenols and parabens to determine associations with preterm birth. RESULTS: We observed moderate variability in urinary phenol and paraben concentrations over pregnancy with intraclass correlation coefficients ranging between 0.45 and 0.68. Regression analyses indicated mostly null associations. We observed inverse associations, notably between 2,5-dichlorophenol and overall preterm birth (adjusted odds ratio [95% confidence interval, CI]: 0.79 [0.67 - 0.94]), and this relationship was consistent by study visit. Conversely, ethyl paraben was associated with increased risk for placental preterm birth (adjusted odds ratio [95% CI]: 1.47 [1.14 - 1.91]). Bisphenol-S detection at visit 4 was associated with overall preterm birth (adjusted odds ratio [95% CI]: 2.05 [1.09, 3.89]). CONCLUSIONS: While the findings from this study largely indicate null associations, we observed some relationships between select phenols, parabens and preterm birth, which warrants further investigation of these toxicants and birth outcomes.
INTRODUCTION:Preterm birth continues to be a significant public heath concern and is a leading cause of perinatal and infantmortality. Environmental exposures to phenols and parabens are suspected to potentially contribute to the pathology of preterm birth, yet limited human studies have characterized the extent to which these toxicants are associated with birth outcomes. METHODS: We examined the associations between phenols, parabens, and preterm birth, within pregnant women who were recruited early in gestation into the LIFECODES cohort at Brigham and Women's Hospital in Boston, Massachusetts. Urine samples were collected at up to 4 time points in pregnancy and analyzed for phenols and parabens. We selected 130 cases of preterm birth (defined as delivery before 37 weeks gestation), and 350 random controls. We categorized preterm birth subtypes based on clinical presentation and identified 75 cases of spontaneous preterm birth (characterized by spontaneous preterm labor and/or preterm premature rupture of membranes), and 37 cases of placental preterm birth (characterized by preeclampsia and/or intrauterine growth restriction). We used multivariate logistic regression with visit specific and geometric averages of phenols and parabens to determine associations with preterm birth. RESULTS: We observed moderate variability in urinary phenol and paraben concentrations over pregnancy with intraclass correlation coefficients ranging between 0.45 and 0.68. Regression analyses indicated mostly null associations. We observed inverse associations, notably between 2,5-dichlorophenol and overall preterm birth (adjusted odds ratio [95% confidence interval, CI]: 0.79 [0.67 - 0.94]), and this relationship was consistent by study visit. Conversely, ethyl paraben was associated with increased risk for placental preterm birth (adjusted odds ratio [95% CI]: 1.47 [1.14 - 1.91]). Bisphenol-S detection at visit 4 was associated with overall preterm birth (adjusted odds ratio [95% CI]: 2.05 [1.09, 3.89]). CONCLUSIONS: While the findings from this study largely indicate null associations, we observed some relationships between select phenols, parabens and preterm birth, which warrants further investigation of these toxicants and birth outcomes.
Authors: Tobias A J Nijman; Elvira O G van Vliet; Manon J N Benders; Ben Willem J Mol; Arie Franx; Peter G J Nikkels; Martijn A Oudijk Journal: Placenta Date: 2016-10-12 Impact factor: 3.481
Authors: David Cantonwine; John D Meeker; Howard Hu; Brisa N Sánchez; Héctor Lamadrid-Figueroa; Adriana Mercado-García; Gamola Z Fortenberry; Antonia M Calafat; Martha Maria Téllez-Rojo Journal: Environ Health Date: 2010-10-18 Impact factor: 5.984
Authors: T F McElrath; J L Hecht; O Dammann; K Boggess; A Onderdonk; G Markenson; M Harper; E Delpapa; E N Allred; A Leviton Journal: Am J Epidemiol Date: 2008-08-27 Impact factor: 4.897
Authors: Yin-Hsiu Chen; Kelly K Ferguson; John D Meeker; Thomas F McElrath; Bhramar Mukherjee Journal: Environ Health Date: 2015-01-26 Impact factor: 5.984
Authors: John D Meeker; Howard Hu; David E Cantonwine; Hector Lamadrid-Figueroa; Antonia M Calafat; Adrienne S Ettinger; Mauricio Hernandez-Avila; Rita Loch-Caruso; Martha María Téllez-Rojo Journal: Environ Health Perspect Date: 2009-06-16 Impact factor: 9.031
Authors: Antonia M Calafat; Lee-Yang Wong; Xiaoyun Ye; John A Reidy; Larry L Needham Journal: Environ Health Perspect Date: 2008-07 Impact factor: 9.031
Authors: Muraly Puttabyatappa; Margaret Banker; Lixia Zeng; Jaclyn M Goodrich; Steven E Domino; Dana C Dolinoy; John D Meeker; Subramaniam Pennathur; Peter X K Song; Vasantha Padmanabhan Journal: J Clin Endocrinol Metab Date: 2020-02-01 Impact factor: 5.958
Authors: Vicente Mustieles; Yu Zhang; Jennifer Yland; Joseph M Braun; Paige L Williams; Blair J Wylie; Jill A Attaman; Jennifer B Ford; Alexandra Azevedo; Antonia M Calafat; Russ Hauser; Carmen Messerlian Journal: Environ Int Date: 2020-02-29 Impact factor: 9.621
Authors: Margaret Banker; Muraly Puttabyatappa; Patrick O'Day; Jaclyn M Goodrich; Angela S Kelley; Steven E Domino; Yolanda R Smith; Dana C Dolinoy; Peter X K Song; Richard J Auchus; Vasantha Padmanabhan Journal: J Clin Endocrinol Metab Date: 2021-03-08 Impact factor: 5.958
Authors: Brennan H Baker; Haotian Wu; Hannah E Laue; Amélie Boivin; Virginie Gillet; Marie-France Langlois; Jean-Philippe Bellenger; Andrea A Baccarelli; Larissa Takser Journal: Environ Int Date: 2020-04-10 Impact factor: 9.621