Literature DB >> 3044829

Effects of glucose on insulin release and 86Rb permeability in cultured neonatal and adult rat islets.

A C Boschero1, D Tombaccini, I Atwater.   

Abstract

Glucose-induced insulin release and modifications in 86Rb outflow were studied in cultured neonatal and adult rat islets. The dose-response curve for neonatal islets was steeper than for adult islets and the maximal response was clearly shifted towards lower glucose concentrations. In neonatal islets, glucose-induced insulin release was inhibited by the Ca2+-channel blocker, nifedipine. In the absence of glucose, the 86Rb outflow from neonatal islets was lower than from adult islets. Also, the glucose-induced reduction in 86Rb outflow was less pronounced in neonatal islets. Altered K+ permeability in the B-cell membrane could explain the change in glucose sensitivity of neonatal islets.

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Year:  1988        PMID： 3044829     DOI： 10.1016/0014-5793(88)80059-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

2.  Effect of the immunosuppressant FK 506 on insulin release from adult rat islets of Langerhans.

Authors:  P B Carroll; A A Gonçalves; A C Boschero; A G Tzakis; T E Starzl; I Atwater
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3.  Effect of the immunosuppressant FK506 on glucose-induced insulin secretion from adult rat islets of Langerhans.

Authors:  P B Carroll; A C Boschero; M Y Li; A G Tzakis; T E Starzl; I Atwater
Journal:  Transplantation       Date:  1991-01       Impact factor: 4.939

4.  Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets.

Authors:  C P F Carvalho; H C L Barbosa; A Britan; J C R Santos-Silva; A C Boschero; P Meda; C B Collares-Buzato
Journal:  Diabetologia       Date:  2010-04-02       Impact factor: 10.122

5.  Upregulation of the expression of tight and adherens junction-associated proteins during maturation of neonatal pancreatic islets in vitro.

Authors:  Carla B Collares-Buzato; Carolina P F Carvalho; Archimedes G Furtado; Antonio C Boschero
Journal:  J Mol Histol       Date:  2004-11       Impact factor: 2.611

6.  Visualising insulin secretion. The Minkowski Lecture 2004.

Authors:  G A Rutter
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Review 7.  Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.

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Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

Review 8.  Purinergic signaling in tanycytes and its contribution to nutritional sensing.

Authors:  Magdiel Salgado; María Á García-Robles; Juan C Sáez
Journal:  Purinergic Signal       Date:  2021-05-21       Impact factor: 3.765
  8 in total

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