B S M S Siriwardena1, Hannah Crane2, Niall O'Neill2, Rasha Abdelkarim2, Daniel J Brierley2, Christopher D Franklin2, Paula M Farthing2, Paul M Speight2, Keith D Hunter3. 1. Unit of Oral and Maxillofacial Medicine, Pathology and Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK; Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka. 2. Unit of Oral and Maxillofacial Medicine, Pathology and Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK. 3. Unit of Oral and Maxillofacial Medicine, Pathology and Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK; Oral Pathology and Biology, University of Pretoria, South Africa. Electronic address: K.hunter@sheffield.ac.uk.
Abstract
OBJECTIVES: Odontogenic tumors (ODTs) are a heterogeneous group of lesions derived from elements of tooth-forming tissues. No detailed data on the incidence of odontogenic tumors in the United Kingdom have been published. The aim of this study was to retrospectively describe the range and incidence of odontogenic tumors from 1992 to 2016 in a single specialist unit and to compare this population with others. STUDY DESIGN: By using the Oral and Maxillofacial Pathology database, Sheffield (UK), we included both local and referred consultation cases. A proportion of diagnoses were reclassified in accordance with the 2017 World Health Organization classification. RESULTS: In total, 559 odontogenic tumors were diagnosed. Overall, the most common lesions were ameloblastoma (196 [33.8%]), odontoma (148 [25.5%]), and odontogenic myxoma (37 [6.3%]), but this varied between local and referral case populations, with odontomas being most common in the local population (43%). The sites affected and the gender and age of patients were similar to other Western populations. Malignant ODTs comprised 33 cases (5.7%), of which 9 (27.3%) were ameloblastic carcinoma. The majority of the malignant ODTs comprised referral cases. CONCLUSIONS: Here, we present the first detailed data on ODTs within a UK population, and the pattern of incidence from the local population is similar to other Western populations. The exceptional rarity of malignant ODTs emphasizes the need for specialist centers for their treatment to gain diagnostic experience.
OBJECTIVES:Odontogenic tumors (ODTs) are a heterogeneous group of lesions derived from elements of tooth-forming tissues. No detailed data on the incidence of odontogenic tumors in the United Kingdom have been published. The aim of this study was to retrospectively describe the range and incidence of odontogenic tumors from 1992 to 2016 in a single specialist unit and to compare this population with others. STUDY DESIGN: By using the Oral and Maxillofacial Pathology database, Sheffield (UK), we included both local and referred consultation cases. A proportion of diagnoses were reclassified in accordance with the 2017 World Health Organization classification. RESULTS: In total, 559 odontogenic tumors were diagnosed. Overall, the most common lesions were ameloblastoma (196 [33.8%]), odontoma (148 [25.5%]), and odontogenic myxoma (37 [6.3%]), but this varied between local and referral case populations, with odontomas being most common in the local population (43%). The sites affected and the gender and age of patients were similar to other Western populations. Malignant ODTs comprised 33 cases (5.7%), of which 9 (27.3%) were ameloblastic carcinoma. The majority of the malignant ODTs comprised referral cases. CONCLUSIONS: Here, we present the first detailed data on ODTs within a UK population, and the pattern of incidence from the local population is similar to other Western populations. The exceptional rarity of malignant ODTs emphasizes the need for specialist centers for their treatment to gain diagnostic experience.
Authors: Marco Mascitti; Lucrezia Togni; Giuseppe Troiano; Vito Carlo Alberto Caponio; Antonio Sabatucci; Andrea Balercia; Corrado Rubini; Lorenzo Lo Muzio; Andrea Santarelli Journal: Eur Arch Otorhinolaryngol Date: 2019-10-14 Impact factor: 2.503
Authors: B S M S Siriwardena; Paul M Speight; Christopher D Franklin; Rasha Abdelkarim; Syed Ali Khurram; Keith D Hunter Journal: Head Neck Pathol Date: 2020-07-08
Authors: Victor Costa; Ana Lia Anbinder; Fernanda Herrera; Nayara Rodrigues; Ana Sueli Rodrigues Cavalcante; Estela Kaminagakura Journal: Head Neck Pathol Date: 2020-08-31