Yun-Ju Lai1, Hsiao-Yun Hu2, Ya-Ling Lee3, Ming-Chung Ko4, Po-Wen Ku5, Yung-Feng Yen6, Dachen Chu7. 1. School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Nantou, Taiwan; Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan. 2. Department of Education and Research, Taipei City Hospital, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan. 3. Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan; Department of Dentistry, Taipei City Hospital, Taipei, Taiwan; Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan. 4. Department of Urology, Taipei City Hospital, Taipei, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. 5. Graduate Institute of Sports and Health, National Changhua University of Education, Changhua, Taiwan. 6. School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; Section of Infectious Diseases, Taipei City Hospital, Taipei City Government, Taipei, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: dam37@tpech.gov.tw. 7. School of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan; Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan; Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan. Electronic address: dad57@tpech.gov.tw.
Abstract
BACKGROUND & AIMS: Alcohol consumption correlates with type 2 diabetes through its effects on insulin resistance, changes in alcohol metabolite levels, and anti-inflammatory effects. We aim to clarify association between frequency of alcohol consumption and risk of diabetes in Taiwanese population. METHODS: The National Health Interview Survey (NHIS) in 2001, 2005, and 2009 selected a representative sample of Taiwan population using a multistage sampling design. Information was collected by standardized face to face interview. Study subjects were connected to the Taiwan National Health Insurance claims dataset and National Register of Deaths Dataset from 2000 to 2013. Kaplan-Meier curve with log rank test was employed to assess the influence of alcohol drinking on incidence of diabetes. Univariate and multivariate Cox proportional regression were used to recognize risk factors of diabetes. RESULTS: A total of 43,000 participants were included (49.65% male; mean age, 41.79 ± 16.31 years). During the 9-year follow-up period, 3650 incident diabetes cases were recognized. Kaplan-Meier curves comparing the four groups of alcohol consumption frequency showed significant differences (p < 0.01). After adjustment for potentially confounding variables, compared to social drinkers, the risks of diabetes were significantly higher for non-drinkers (adjusted hazard ratio [AHR] = 1.21; 95% confidence interval [CI], 1.09-1.34; p < 0.01), regular drinkers (AHR = 1.19; 95% CI, 1.06-1.35; p < 0.01), and heavy drinkers (AHR = 2.21, 95% CI, 1.56-3.13, p < 0.01). CONCLUSIONS: Social drinkers have a significantly decreased risk of new-onset diabetes compared with non-, regular, and heavy drinkers.
BACKGROUND & AIMS:Alcohol consumption correlates with type 2 diabetes through its effects on insulin resistance, changes in alcohol metabolite levels, and anti-inflammatory effects. We aim to clarify association between frequency of alcohol consumption and risk of diabetes in Taiwanese population. METHODS: The National Health Interview Survey (NHIS) in 2001, 2005, and 2009 selected a representative sample of Taiwan population using a multistage sampling design. Information was collected by standardized face to face interview. Study subjects were connected to the Taiwan National Health Insurance claims dataset and National Register of Deaths Dataset from 2000 to 2013. Kaplan-Meier curve with log rank test was employed to assess the influence of alcohol drinking on incidence of diabetes. Univariate and multivariate Cox proportional regression were used to recognize risk factors of diabetes. RESULTS: A total of 43,000 participants were included (49.65% male; mean age, 41.79 ± 16.31 years). During the 9-year follow-up period, 3650 incident diabetes cases were recognized. Kaplan-Meier curves comparing the four groups of alcohol consumption frequency showed significant differences (p < 0.01). After adjustment for potentially confounding variables, compared to social drinkers, the risks of diabetes were significantly higher for non-drinkers (adjusted hazard ratio [AHR] = 1.21; 95% confidence interval [CI], 1.09-1.34; p < 0.01), regular drinkers (AHR = 1.19; 95% CI, 1.06-1.35; p < 0.01), and heavy drinkers (AHR = 2.21, 95% CI, 1.56-3.13, p < 0.01). CONCLUSIONS: Social drinkers have a significantly decreased risk of new-onset diabetes compared with non-, regular, and heavy drinkers.
Authors: Rebecca G Kim; Jonathan Kramer-Feldman; Peter Bacchetti; Barbara Grimes; Esteban Burchard; Celeste Eng; Donglei Hu; Marc Hellerstein; Mandana Khalili Journal: Alcohol Clin Exp Res Date: 2021-11-23 Impact factor: 3.455
Authors: Blake Byron Walker; Sebastian Tobias Brinkmann; Tim Große; Dominik Kremer; Nadine Schuurman; Perry Hystad; Sumathy Rangarajan; Koon Teo; Salim Yusuf; Scott A Lear Journal: J Urban Health Date: 2022-05-12 Impact factor: 5.801