| Literature DB >> 30447209 |
Abstract
Myocardial relaxation is critical for the heart to allow for adequate filling of the ventricles prior to the next contraction. In human heart failure, impairment of myocardial relaxation is a major problem, and impacts most patients suffering from end-stage failure. Furthering our understanding of myocardial relaxation is critical in developing future treatment strategies. This review highlights processes involved in myocardial relaxation, as well as governing processes that modulate myocardial relaxation, with a focus on impairment of myocardium-level relaxation in human end-stage heart failure.Entities:
Keywords: Calcium; Contraction; Heart disease; Myofilaments
Mesh:
Year: 2018 PMID: 30447209 PMCID: PMC6311133 DOI: 10.1016/j.abb.2018.11.011
Source DB: PubMed Journal: Arch Biochem Biophys ISSN: 0003-9861 Impact factor: 4.013