Hao Zhou1,2, Chun-Pei Li1, Yi Huang3, Xiao-Bing Zou4, Xue-Rong Luo5, Li-Jie Wu6, Lan Zhang7, Xiu Xu8, Wei-Li Yan9, Yi Wang10,11. 1. Department of Neurology, Children's Hospital of Fudan University, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China. 2. Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, 550002, China. 3. Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, 610041, China. 4. Child Developmental-Behavioral Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. 5. Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410008, China. 6. School of Public Health, Harbin Medical University, Harbin, 150081, China. 7. Department of Child Health, Chengdu Women and Children's Hospital, Chengdu, 610091, China. 8. Department of Child Health, Children's Hospital of Fudan University, Shanghai, 201102, China. 9. Department of Clinical Epidemiology, Children's Hospital of Fudan University, Shanghai, 201102, China. 10. Department of Neurology, Children's Hospital of Fudan University, No. 399 Wanyuan Road, Minhang District, Shanghai, 201102, China. yiwang@shmu.edu.cn. 11. State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201132, China. yiwang@shmu.edu.cn.
Abstract
BACKGROUND: Early autism screening is of great value, but there is lack of a screening tool of early age (2-5 years) in China. The Autism Spectrum Rating Scale (ASRS, 2-5 years) is a newly developed autism screening tool in the USA. This study aimed to evaluate the reliability and validity of the translated Chinese version of ASRS (C_ASRS) in Chinese children population before its application in China for early autism screening. METHODS: Caregivers of general children aged 2-5 years from 17 kindergartens and autism spectrum disorder (ASD) cases from five special education schools in five cities were recruited to complete the C_ASRS. 1910 valid questionnaires from kindergarteners and 192 from ASD cases were included for analyses. RESULTS: The item reliability (Cronbach's alpha) was more than 0.80 in the screening scale and DSM-5 scale, and 0.51-0.81 in the treatment scale. ASD cases scored higher on total score and most subscales compared to the kindergarteners (Cohen's d ranging from 1.34 to 3.37). C_ASRS showed good discriminatory validity with an area under the receiver operating characteristic curve of 0.850 (95% confidence interval: 0.819-0.881). The cutoff ≥ 60 achieved sensitivity of 65.63% and specificity of 85.63% in discriminating autism children from the general population. CONCLUSION: The results indicate that C_ASRS (2-5 years) could be used as an early level-2 screening tool for autism screening in China and should be further revised for level-1 screening.
BACKGROUND: Early autism screening is of great value, but there is lack of a screening tool of early age (2-5 years) in China. The Autism Spectrum Rating Scale (ASRS, 2-5 years) is a newly developed autism screening tool in the USA. This study aimed to evaluate the reliability and validity of the translated Chinese version of ASRS (C_ASRS) in Chinese children population before its application in China for early autism screening. METHODS: Caregivers of general children aged 2-5 years from 17 kindergartens and autism spectrum disorder (ASD) cases from five special education schools in five cities were recruited to complete the C_ASRS. 1910 valid questionnaires from kindergarteners and 192 from ASD cases were included for analyses. RESULTS: The item reliability (Cronbach's alpha) was more than 0.80 in the screening scale and DSM-5 scale, and 0.51-0.81 in the treatment scale. ASD cases scored higher on total score and most subscales compared to the kindergarteners (Cohen's d ranging from 1.34 to 3.37). C_ASRS showed good discriminatory validity with an area under the receiver operating characteristic curve of 0.850 (95% confidence interval: 0.819-0.881). The cutoff ≥ 60 achieved sensitivity of 65.63% and specificity of 85.63% in discriminating autismchildren from the general population. CONCLUSION: The results indicate that C_ASRS (2-5 years) could be used as an early level-2 screening tool for autism screening in China and should be further revised for level-1 screening.
Authors: Xiang Sun; Carrie Allison; Bonnie Auyeung; Fiona E Matthews; Stephen J Sharp; Simon Baron-Cohen; Carol Brayne Journal: J Autism Dev Disord Date: 2014-09
Authors: Xiang Sun; Carrie Allison; Bonnie Auyeung; Fiona E Matthews; Zhixiang Zhang; Simon Baron-Cohen; Carol Brayne Journal: Res Dev Disabil Date: 2014-04-25