| Literature DB >> 30446310 |
Manpreet Kaur1, Palwinder Singh2.
Abstract
Based on the molecular modelling studies, a rational modification of the lead molecule was made to develop highly potent compounds showing anti-cancer activity against human breast cancer cell lines MCF 7, MDA-MB-468 and T-47D. The most potent compounds have Log P and total polar surface area 4.4-5.4 and 59.8 Å, respectively and they also exhibited promising ADME profile.Entities:
Keywords: Acridone; Anticancer; Molecular modeling; Oxindole; Pyrrole; Tyrosine kinase
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Year: 2018 PMID： 30446310 DOI： 10.1016/j.bmcl.2018.11.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823