Literature DB >> 30446211

Geroneuroprotectors: Effective Geroprotectors for the Brain.

David Schubert1, Antonio Currais1, Joshua Goldberg1, Kim Finley2, Michael Petrascheck3, Pamela Maher4.   

Abstract

Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; aging; drug discovery; geroscience; multimorbidity; neuroprotection

Mesh：

Substances：

Year:  2018        PMID： 30446211      PMCID： PMC6558984          DOI： 10.1016/j.tips.2018.09.008

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  20 in total

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Review 2.  Cellular and molecular mechanisms of metformin: an overview.

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5.  Chemical modification of the multitarget neuroprotective compound fisetin.

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Review 6.  mTOR is a key modulator of ageing and age-related disease.

Authors:  Simon C Johnson; Peter S Rabinovitch; Matt Kaeberlein
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962

7.  An antidepressant that extends lifespan in adult Caenorhabditis elegans.

Authors:  Michael Petrascheck; Xiaolan Ye; Linda B Buck
Journal:  Nature       Date:  2007-11-22       Impact factor: 49.962

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Journal:  J Biol Chem       Date:  2012-12-21       Impact factor: 5.157

9.  A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

Authors:  Qi Chen; Marguerite Prior; Richard Dargusch; Amanda Roberts; Roland Riek; Cédric Eichmann; Chandramouli Chiruta; Tatsuhiro Akaishi; Kazuho Abe; Pamela Maher; David Schubert
Journal:  PLoS One       Date:  2011-12-14       Impact factor: 3.240

10.  Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice.

Authors:  Antonio Currais; Marguerite Prior; Richard Dargusch; Aaron Armando; Jennifer Ehren; David Schubert; Oswald Quehenberger; Pamela Maher
Journal:  Aging Cell       Date:  2013-12-17       Impact factor: 9.304
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  18 in total

Review 1.  Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease.

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Journal:  Medchemcomm       Date:  2019-04-30       Impact factor: 3.597

2.  Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors.

Authors:  Zhibin Liang; David Soriano-Castell; Devin Kepchia; Brendan M Duggan; Antonio Currais; David Schubert; Pamela Maher
Journal:  Free Radic Biol Med       Date:  2022-01-06       Impact factor: 7.376

Review 3.  Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer's Disease.

Authors:  Tamas Fulop; Shreyansh Tripathi; Serafim Rodrigues; Mathieu Desroches; Ton Bunt; Arnold Eiser; Francois Bernier; Pascale B Beauregard; Annelise E Barron; Abdelouahed Khalil; Adam Plotka; Katsuiku Hirokawa; Anis Larbi; Christian Bocti; Benoit Laurent; Eric H Frost; Jacek M Witkowski
Journal:  Neuropsychiatr Dis Treat       Date:  2021-05-04       Impact factor: 2.570

4.  The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.

Authors:  Devin Kepchia; Ling Huang; Antonio Currais; Zhibin Liang; Wolfgang Fischer; Pamela Maher
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Review 5.  The search for anti-oxytotic/ferroptotic compounds in the plant world.

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Journal:  Br J Pharmacol       Date:  2021-06-06       Impact factor: 9.473

6.  Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease.

Authors:  Pamela A Maher
Journal:  Yale J Biol Med       Date:  2020-06-29

Review 7.  Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.

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Review 8.  Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders.

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Journal:  Pharmacol Ther       Date:  2020-11-20       Impact factor: 12.310

9.  The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus Eriodictyon.

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Journal:  Front Pharmacol       Date:  2020-03-10       Impact factor: 5.810

Review 10.  Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases.

Authors:  Pamela Maher; Antonio Currais; David Schubert
Journal:  Cell Chem Biol       Date:  2020-11-10       Impact factor: 8.116
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