Jun-Sang Sunwoo1, Kwang Su Cha2, Jung-Ick Byun3, Tae-Joon Kim4, Jin-Sun Jun5, Jung-Ah Lim6, Soon-Tae Lee2,7, Keun-Hwa Jung2,7, Kyung-Il Park8, Kon Chu2,7, Han-Joon Kim2, Manho Kim2,7,9, Sang Kun Lee2,7,10, Kyung Hwan Kim11, Carlos H Schenck12, Ki-Young Jung2,7,10. 1. Department of Neurology, Soonchunhyang University College of Medicine, Seoul, South Korea. 2. Department of Neurology, Seoul National University Hospital, Seoul, South Korea. 3. Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea. 4. Department of Neurology, National Center for Mental Health, Seoul, South Korea. 5. Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea. 6. Department of Neurology, Gangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea. 7. Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea. 8. Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea. 9. Protein Metabolism Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. 10. Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, South Korea. 11. Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, South Korea. 12. Minnesota Regional Sleep Disorders Center, and Department of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis, MN.
Abstract
Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6%) and 10 controls (mean age, 62.3 years; men, 70%) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.
Study Objectives: We investigated electroencephalography (EEG) power spectral density and functional connectivity during phasic and tonic rapid eye movement (REM) sleep, and examined any differences between patients with idiopathic REM sleep behavior disorder (iRBD) and controls. Methods: EEG data from 13 people with iRBD (mean age, 66.3 years; men, 84.6%) and 10 controls (mean age, 62.3 years; men, 70%) were analyzed. We selected thirty 3 s miniepochs of both tonic and phasic REM sleep. We estimated relative power for six frequency bands. For functional connectivity analysis, we calculated weighted phase lag index (wPLI) and conducted pairwise comparisons between the two groups. Results: EEG power spectral analysis revealed significant interactions between the REM sleep state (phasic vs. tonic) and group at sigma (p = 0.009) and beta (p = 0.002) bands. Sigma- and beta-power decrease during phasic REM sleep was more pronounced and extensive in people with iRBD than in controls. Regarding functional connectivity, there were significant interactions between the REM sleep state and group at alpha (p = 0.029), sigma (p = 0.047), beta (p = 0.015), and gamma (p = 0.046) bands. The average wPLI was significantly higher during phasic REM sleep than during tonic REM sleep, which was observed in people with iRBD but not in controls. The altered functional connections mainly involved the frontal and parietal regions at beta and gamma bands. Conclusions: Our findings provide neurophysiological evidence for pathological motor cortex activation during phasic REM sleep which may be associated with generation of dream-enacting behaviors in iRBD.
Authors: Amandine Valomon; Brady A Riedner; Stephanie G Jones; Keith P Nakamura; Giulio Tononi; David T Plante; Ruth M Benca; Melanie Boly Journal: Sci Rep Date: 2021-02-26 Impact factor: 4.379
Authors: Jun Sang Sunwoo; Young Ji Kim; Jung Ick Byun; Tae Joon Kim; Jin Sun Jun; Soon Tae Lee; Keun Hwa Jung; Kyung Il Park; Kon Chu; Manho Kim; Sang Kun Lee; Han Joon Kim; Carlos H Schenck; Ki Young Jung Journal: J Clin Neurol Date: 2020-04 Impact factor: 3.077
Authors: Gyeong Seon Choi; Ji Young Yun; Sungeun Hwang; Song E Kim; Jeong-Yeon Kim; Chang-Hwan Im; Hyang Woon Lee Journal: J Clin Med Date: 2021-11-27 Impact factor: 4.241