Yukihiro Imaoka1, Takayuki Kawano2, Akihito Hashiguchi3, Kenji Fujimoto2, Keizou Yamamoto4, Toru Nishi5, Tadahiro Otsuka6, Shigetoshi Yano2, Akitake Mukasa2. 1. Department of Neurosurgery, Hitoyoshi Medical Center, 35 Oigamicho, Hitoyoshi city, Kumamoto, 868-8555, Japan; Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto city, Kumamoto, 860-8556, Japan. Electronic address: yukihiro.imaoka@gmail.com. 2. Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto city, Kumamoto, 860-8556, Japan. 3. Department of Neursurgery, Tokuda Neurosurgical Hospital, 1-11248-1 Utsuma, Kanoya city, Kagoshima, 893-0011, Japan. 4. Department of Neurosurgery, Hitoyoshi Medical Center, 35 Oigamicho, Hitoyoshi city, Kumamoto, 868-8555, Japan. 5. Department of Neurosurgery, Saiseikai Kumamoto Hosipital, 5-3-1 Chikami, Kumamoto city, Kumamoto, 861-4193, Japan. 6. Department of Neurosurgery, National Medical Organization Kumamoto Medical Center, 1-5 Ninomaru, Kumamoto city, Kumamoto, 860-0008, Japan.
Abstract
OBJECTIVES: Frailty is an indispensable concept among elderly. The purpose of this study was to determine the association between modified frailty index (mFI) and the postoperative outcome of surgery for spontaneous intracerebral hemorrhage (sICH). PATIENTS AND METHODS: Outcome measures included an unfavorable outcome (modified Rankin Scale score of 4-6) or mortality at 6-8 months after hemorrhage. The prognostic ability of mFI was assessed by comparing adjusted and nonadjusted effects with the Hemphill's ICH score. The performance of the ICH score combined with mFI was assessed for discriminative ability. RESULTS: In total, 156 patients satisfied the inclusion criteria. Multivariate analyses revealed that higher mFI was significantly associated with an unfavorable outcome (p-value = 0.004) and mortality (p-value < 0.001). Compared with the ICH score alone, the ICH score combined with mFI revealed significantly higher discriminative ability for predicting postoperative outcome. CONCLUSION: mFI was a useful and reliable predictor of postoperative unfavorable outcome for sICH. Frailty may be an important essence to be considered before operation for sICS in the aging society.
OBJECTIVES: Frailty is an indispensable concept among elderly. The purpose of this study was to determine the association between modified frailty index (mFI) and the postoperative outcome of surgery for spontaneous intracerebral hemorrhage (sICH). PATIENTS AND METHODS: Outcome measures included an unfavorable outcome (modified Rankin Scale score of 4-6) or mortality at 6-8 months after hemorrhage. The prognostic ability of mFI was assessed by comparing adjusted and nonadjusted effects with the Hemphill's ICH score. The performance of the ICH score combined with mFI was assessed for discriminative ability. RESULTS: In total, 156 patients satisfied the inclusion criteria. Multivariate analyses revealed that higher mFI was significantly associated with an unfavorable outcome (p-value = 0.004) and mortality (p-value < 0.001). Compared with the ICH score alone, the ICH score combined with mFI revealed significantly higher discriminative ability for predicting postoperative outcome. CONCLUSION: mFI was a useful and reliable predictor of postoperative unfavorable outcome for sICH. Frailty may be an important essence to be considered before operation for sICS in the aging society.
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