Zoltan Griger1, Katalin Danko1, Levente Bodoki1, Zsuzsa Aszalos1, Gabor Nemeth2,3, Hassan Ziad4, Rudolf Gesztelyi5, Judit Zsuga6, Peter Szodoray7, Adam Kemeny-Beke2. 1. Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. 2. Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. 3. Department of Ophthalmology, Borsod-Abauj-Zemplen County Hospital and University Teaching Hospital, Miskolc, Hungary. 4. Orbi-Dent Refractive Surgery and Medical Centre, Debrecen, Hungary. 5. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. 6. Department of Health Systems Management and Quality Management in Health Care, Faculty of Public Health, University of Debrecen, Debrecen, Hungary. 7. Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Abstract
Purpose: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls. Methods: A total of 43 PM and 32 DM patients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Objective clinical tests of dry eye disease (DED) were also performed. Results: All pachymetric measurements and corneal volumes (CVs) proved to be significantly lower both in PM and DM patients. The values of DM patients were closer to control values than those of the PM patients. For tear break-up time and Schirmer-I test values significant differences were observed between patients and controls, with values decreased both in PM and DM patients.Conclusions: PM patients rather than DM patients tend to develop thinner and low-volume corneas as compared to controls. Additionally, a high prevalence of DED among both PM and DM patients was also detected.
Purpose: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls. Methods: A total of 43 PM and 32 DMpatients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Objective clinical tests of dry eye disease (DED) were also performed. Results: All pachymetric measurements and corneal volumes (CVs) proved to be significantly lower both in PM and DMpatients. The values of DMpatients were closer to control values than those of the PM patients. For tear break-up time and Schirmer-I test values significant differences were observed between patients and controls, with values decreased both in PM and DMpatients.Conclusions: PM patients rather than DMpatients tend to develop thinner and low-volume corneas as compared to controls. Additionally, a high prevalence of DED among both PM and DMpatients was also detected.