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Literature DB >> 30443833

The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review.

Chenran Zhang^1,2,3,4, Frederick A Boop^5,6,7,8, John Ruge⁹.

Abstract

The compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors.

Entities: Chemical Disease Species

Keywords: 5-Aminolevulinic acid (5-ALA); Extent of resection; Pediatric brain tumor

Mesh：

Substances：

Year: 2018 PMID： 30443833 DOI： 10.1007/s11060-018-03004-y

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

32 in total

1. Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA.

Authors: Walter Stummer; Ulf Nestler; Florian Stockhammer; Dietmar Krex; Bodo C Kern; Hubert M Mehdorn; Giles H Vince; Uwe Pichlmeier
Journal: J Neurooncol Date: 2010-10-05 Impact factor: 4.130

2. ALA-induced porphyrin accumulation in medulloblastoma and its use for fluorescence-guided surgery.

Authors: S Eicker; S Sarikaya-Seiwert; A Borkhardt; K Gierga; B Turowski; H-J Heiroth; H-J Steiger; W Stummer
Journal: Cent Eur Neurosurg Date: 2010-10-07

3. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.

Authors: Walter Stummer; Uwe Pichlmeier; Thomas Meinel; Otmar Dieter Wiestler; Friedhelm Zanella; Hans-Jürgen Reulen
Journal: Lancet Oncol Date: 2006-05 Impact factor: 41.316

4. Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.

Authors: Nader Sanai; Laura A Snyder; Norissa J Honea; Stephen W Coons; Jennifer M Eschbacher; Kris A Smith; Robert F Spetzler
Journal: J Neurosurg Date: 2011-07-15 Impact factor: 5.115

5. Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article.

Authors: Walter Stummer; Jörg-Christian Tonn; Hubertus Maximilian Mehdorn; Ulf Nestler; Kea Franz; Claudia Goetz; Andrea Bink; Uwe Pichlmeier
Journal: J Neurosurg Date: 2010-04-16 Impact factor: 5.115

6. Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies.

Authors: Christof M Kramm; Sabine Wagner; Stefan Van Gool; Hansjörg Schmid; Ronald Sträter; Astrid Gnekow; Stefan Rutkowski; Johannes E A Wolff
Journal: Anticancer Res Date: 2006 Sep-Oct Impact factor: 2.480

7. Use of 5-aminolevulinic acid for visualization and resection of a benign pediatric brain tumor.

Authors: John R Ruge; Jonathan Liu
Journal: J Neurosurg Pediatr Date: 2009-11 Impact factor: 2.375

8. Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report.

Authors: Walter Stummer; Tobias Beck; Wolfgang Beyer; Jan Hendrik Mehrkens; Andreas Obermeier; Nima Etminan; Herbert Stepp; Jörg-Christian Tonn; Reinhold Baumgartner; Jochen Herms; Friedrich Wilhelm Kreth
Journal: J Neurooncol Date: 2007-11-23 Impact factor: 4.130

9. Advances in surgical techniques for resection of childhood cerebellopontine angle ependymomas are key to survival.

Authors: Robert A Sanford; Thomas E Merchant; Marike Zwienenberg-Lee; Larry E Kun; Frederick A Boop
Journal: Childs Nerv Syst Date: 2009-05-30 Impact factor: 1.475

10. Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.

Authors: L Teng; M Nakada; S-G Zhao; Y Endo; N Furuyama; E Nambu; I V Pyko; Y Hayashi; J-I Hamada
Journal: Br J Cancer Date: 2011-02-08 Impact factor: 7.640

9 in total

1. 5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope.

Authors: Peter Milos; Neda Haj-Hosseini; Jan Hillman; Karin Wårdell
Journal: Acta Neurochir (Wien) Date: 2022-10-15 Impact factor: 2.816

2. 5-Aminolevulinic acid-assisted resection of pediatric dysembryoplastic neuroepithelial tumor: illustrative case.

Authors: Luke H Beauchamp; Marian Michael Bercu; Anthony M Avellino
Journal: J Neurosurg Case Lessons Date: 2021-07-26

3. The Role of 5-ALA in Low-Grade Gliomas and the Influence of Antiepileptic Drugs on Intraoperative Fluorescence.

Authors: Sergey A Goryaynov; Georg Widhalm; Maria F Goldberg; Danil Chelushkin; Aldo Spallone; Kosta A Chernyshov; Marina Ryzhova; Galina Pavlova; Alexander Revischin; Ludmila Shishkina; Vadim Jukov; Tatyana Savelieva; Loschenov Victor; Alexander Potapov
Journal: Front Oncol Date: 2019-05-22 Impact factor: 6.244