Literature DB >> 3044377

Tetanus booster every 5 years: an unnecessary routine?

C G Chikhani1, K Kumar.   

Abstract

The various guidelines for the administration of tetanus toxoid and antitetanus immunoglobulin are not only complicated, but also have never been supported by any scientific experimental studies. This study has measured the antibody levels in a random sample of 157 patients presenting to an accident and emergency department. Levels were measured before and after boosting doses. The results show that, in the sample analyzed, even those patients who had their last 'booster' over 10 years ago, had a satisfactory immunoglobulin level. In fact, no patient in the study had a level below the 'protective level'. Bearing in mind the small number of patients in the study, it could be argued that the level of immunity against tetanus in the United Kingdom is likely to be higher than assumed. If this is proven to be correct, then the length of time between booster injections of toxoid can be extended and the use of Human Antitetanus Immunoglobulin can be further restricted.

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Year:  1988        PMID: 3044377      PMCID: PMC1285469          DOI: 10.1136/emj.5.1.4

Source DB:  PubMed          Journal:  Arch Emerg Med        ISSN: 0264-4924


  12 in total

1.  Residual antitetanus protection 17 to 19 years after active immunization.

Authors:  R K WORMAN; Z KISS; F A CAMP; K E McDONALD; W G SCHENK
Journal:  Surg Gynecol Obstet       Date:  1963-05

2.  The uses and results of active tetanus immunization.

Authors:  I SCHEIBEL
Journal:  Bull World Health Organ       Date:  1955       Impact factor: 9.408

3.  The prevention of tetanus: which direction for improvement?

Authors:  J Marrow
Journal:  Arch Emerg Med       Date:  1986-12

4.  Duration of immunity after active immunisation against tetanus.

Authors:  W G White; G M Barnes; A H Griffith; D Gall; E Barker; J W Smith
Journal:  Lancet       Date:  1969-07-12       Impact factor: 79.321

5.  Tetanus-toxoid emergency boosters: a reappraisal.

Authors:  T C Peebles; L Levine; M C Eldred; G Edsall
Journal:  N Engl J Med       Date:  1969-03-13       Impact factor: 91.245

6.  Prevention of tetanus in the wounded.

Authors:  J W Smith; D R Laurence; D G Evans
Journal:  Br Med J       Date:  1975-08-23

7.  Intensive care in tetanus: management, complications, and mortality in 100 cases.

Authors:  R S Edmondson; M W Flowers
Journal:  Br Med J       Date:  1979-05-26

8.  Reactions and antibody responses to reinforcing doses of adsorbed and plain tetanus vaccines.

Authors:  L H Collier; S Polakoff; J Mortimer
Journal:  Lancet       Date:  1979-06-30       Impact factor: 79.321

9.  Misuse of tetanus immunoprophylaxis in wound care.

Authors:  J Giangrasso; R K Smith
Journal:  Ann Emerg Med       Date:  1985-06       Impact factor: 5.721

10.  Immunization against tetanus of patients given injections of antitetanus serum.

Authors:  A TASMAN; F J HUYGEN
Journal:  Bull World Health Organ       Date:  1962       Impact factor: 9.408

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