Literature DB >> 30443047

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

Arun K Ghosh1, Dongwoo Shin1, Debbie Downs2, Gerald Koelsch2, Xinli Lin2, Jacques Ermolieff2, Jordan Tang2,3.   

Abstract

Entities:  

Year:  2000        PMID： 30443047      PMCID： PMC6233310          DOI： 10.1021/ja000300g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  13 in total

Review 1.  The penetration of anti-infectives into the central nervous system.

Authors:  B P Kearney; F T Aweeka
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2.  Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Authors:  I Hussain; D Powell; D R Howlett; D G Tew; T D Meek; C Chapman; I S Gloger; K E Murphy; C D Southan; D M Ryan; T S Smith; D L Simmons; F S Walsh; C Dingwall; G Christie
Journal:  Mol Cell Neurosci       Date:  1999-12       Impact factor: 4.314

3.  Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Authors:  R Yan; M J Bienkowski; M E Shuck; H Miao; M C Tory; A M Pauley; J R Brashier; N C Stratman; W R Mathews; A E Buhl; D B Carter; A G Tomasselli; L A Parodi; R L Heinrikson; M E Gurney
Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

4.  Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Authors:  S Sinha; J P Anderson; R Barbour; G S Basi; R Caccavello; D Davis; M Doan; H F Dovey; N Frigon; J Hong; K Jacobson-Croak; N Jewett; P Keim; J Knops; I Lieberburg; M Power; H Tan; G Tatsuno; J Tung; D Schenk; P Seubert; S M Suomensaari; S Wang; D Walker; J Zhao; L McConlogue; V John
Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

Review 5.  The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.

Authors:  D J Selkoe
Journal:  Trends Cell Biol       Date:  1998-11       Impact factor: 20.808

Review 6.  Translating cell biology into therapeutic advances in Alzheimer's disease.

Authors:  D J Selkoe
Journal:  Nature       Date:  1999-06-24       Impact factor: 49.962

7.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Authors:  R Vassar; B D Bennett; S Babu-Khan; S Kahn; E A Mendiaz; P Denis; D B Teplow; S Ross; P Amarante; R Loeloff; Y Luo; S Fisher; J Fuller; S Edenson; J Lile; M A Jarosinski; A L Biere; E Curran; T Burgess; J C Louis; F Collins; J Treanor; G Rogers; M Citron
Journal:  Science       Date:  1999-10-22       Impact factor: 47.728

8.  Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.

Authors:  X Lin; G Koelsch; S Wu; D Downs; A Dashti; J Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

Review 9.  Renin inhibitors.

Authors:  W J Greenlee
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10.  Mode of inhibition of acid proteases by pepstatin.

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Journal:  J Biol Chem       Date:  1976-11-25       Impact factor: 5.157
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Review 1.  beta-Secretase as a therapeutic target for Alzheimer's disease.

Authors:  Arun K Ghosh; Sandra Gemma; Jordan Tang
Journal:  Neurotherapeutics       Date:  2008-07       Impact factor: 7.620

2.  Current experimental therapy for Alzheimer's disease.

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Journal:  Curr Neuropharmacol       Date:  2007       Impact factor: 7.363

Review 3.  Organic carbamates in drug design and medicinal chemistry.

Authors:  Arun K Ghosh; Margherita Brindisi
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4.  Hybrid approach to sieve out natural compounds against dual targets in Alzheimer's Disease.

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Journal:  Sci Rep       Date:  2019-03-06       Impact factor: 4.379

5.  Is It the Twilight of BACE1 Inhibitors?

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6.  Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35.

Authors:  Mengying Wei; Yuanyuan Liu; Zifeng Pi; Kexin Yue; Shizhe Li; Mingxin Hu; Zhiqiang Liu; Fengrui Song; Zhongying Liu
Journal:  RSC Adv       Date:  2019-06-10       Impact factor: 4.036

Review 7.  Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Authors:  Jordan Tang; Arun K Ghosh; Lin Hong; Gerald Koelsch; Robert T Turner; Wanpin Chang
Journal:  J Mol Neurosci       Date:  2003       Impact factor: 2.866

8.  Conformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation Equilibria.

Authors:  M Olivia Kim; Patrick G Blachly; J Andrew McCammon
Journal:  PLoS Comput Biol       Date:  2015-10-27       Impact factor: 4.475

Review 9.  New directions for protease inhibitors directed drug discovery.

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Review 10.  Targeting Amyloidogenic Processing of APP in Alzheimer's Disease.

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Journal:  Front Mol Neurosci       Date:  2020-08-04       Impact factor: 5.639
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