D Mata-Mbemba1, Y Iimura2, L-N Hazrati3, A Ochi2, H Otsubo2, O C Snead2, J Rutka4, E Widjaja5,2. 1. From the Department of Diagnostic Imaging (D.M.-M., E.W.). 2. Division of Neurology (Y.I., A.O., H.O., O.C.S., E.W.). 3. Departments of Pathology (L.-N.H.). 4. Neurosurgery (J.R.), The Hospital for Sick Children, University of Toronto, Ontario, Canada. 5. From the Department of Diagnostic Imaging (D.M.-M., E.W.) Elysa.Widjaja@sickkids.ca.
Abstract
BACKGROUND AND PURPOSE: Abnormalities of oligodendrocytes have been reported in surgical specimens of patients with medically intractable epilepsy. The aim of this study was to compare the MR imaging, magnetoencephalography, and surgical outcome of children with oligodendrocytosis relative to focal cortical dysplasia I. MATERIALS AND METHODS: Oligodendrocytosis included oligodendroglial hyperplasia, oligodendrogliosis, and oligodendroglial-like cells in the white matter, gray matter, or both from children with medically intractable epilepsy. Focal cortical dysplasia I included radial and tangential cortical dyslamination. The MR imaging, magnetoencephalography, type of operation, location, and seizure outcome of oligodendrocytosis, focal cortical dysplasia I, and oligodendrocytosis + focal cortical dysplasia I were compared. RESULTS: Eighteen subjects (39.1%) had oligodendrocytosis, 21 (45.7%) had focal cortical dysplasia I, and 7 (15.2%) had oligodendrocytosis + focal cortical dysplasia I. There were no significant differences in the type of seizures, focal or nonfocal epileptiform discharges, magnetoencephalography, and MR imaging features, including high T1 signal in the cortex, high T2/FLAIR signal in the cortex or subcortical white matter, increased cortical thickness, blurring of the gray-white junction, or abnormal sulcation and gyration among those with oligodendrocytosis, focal cortical dysplasia I, or oligodendrocytosis + focal cortical dysplasia I (P > .01). There were no significant differences in the extent of resection (unilobar versus multilobar versus hemispherectomy), location of the operation (temporal versus extratemporal versus both), or seizure-free outcome of oligodendrocytosis, focal cortical dysplasia I, and oligodendrocytosis + focal cortical dysplasia I (P > .05). CONCLUSIONS: Oligodendrocytosis shared MR imaging and magnetoencephalography features with focal cortical dysplasia I, and multilobar resection was frequently required to achieve seizure freedom. In 15% of cases, concurrent oligodendrocytosis and focal cortical dysplasia I were identified. The findings suggest that oligodendrocytosis may represent a mild spectrum of malformations of cortical development.
BACKGROUND AND PURPOSE: Abnormalities of oligodendrocytes have been reported in surgical specimens of patients with medically intractable epilepsy. The aim of this study was to compare the MR imaging, magnetoencephalography, and surgical outcome of children with oligodendrocytosis relative to focal cortical dysplasia I. MATERIALS AND METHODS: Oligodendrocytosis included oligodendroglial hyperplasia, oligodendrogliosis, and oligodendroglial-like cells in the white matter, gray matter, or both from children with medically intractable epilepsy. Focal cortical dysplasia I included radial and tangential cortical dyslamination. The MR imaging, magnetoencephalography, type of operation, location, and seizure outcome of oligodendrocytosis, focal cortical dysplasia I, and oligodendrocytosis + focal cortical dysplasia I were compared. RESULTS: Eighteen subjects (39.1%) had oligodendrocytosis, 21 (45.7%) had focal cortical dysplasia I, and 7 (15.2%) had oligodendrocytosis + focal cortical dysplasia I. There were no significant differences in the type of seizures, focal or nonfocal epileptiform discharges, magnetoencephalography, and MR imaging features, including high T1 signal in the cortex, high T2/FLAIR signal in the cortex or subcortical white matter, increased cortical thickness, blurring of the gray-white junction, or abnormal sulcation and gyration among those with oligodendrocytosis, focal cortical dysplasia I, or oligodendrocytosis + focal cortical dysplasia I (P > .01). There were no significant differences in the extent of resection (unilobar versus multilobar versus hemispherectomy), location of the operation (temporal versus extratemporal versus both), or seizure-free outcome of oligodendrocytosis, focal cortical dysplasia I, and oligodendrocytosis + focal cortical dysplasia I (P > .05). CONCLUSIONS: Oligodendrocytosis shared MR imaging and magnetoencephalography features with focal cortical dysplasia I, and multilobar resection was frequently required to achieve seizure freedom. In 15% of cases, concurrent oligodendrocytosis and focal cortical dysplasia I were identified. The findings suggest that oligodendrocytosis may represent a mild spectrum of malformations of cortical development.
Authors: Koji Iida; Hiroshi Otsubo; Yuuri Matsumoto; Ayako Ochi; Makoto Oishi; Stephanie Holowka; Elizabeth Pang; Irene Elliott; Shelly K Weiss; Sylvester H Chuang; O Carter Snead; James T Rutka Journal: J Neurosurg Date: 2005-03 Impact factor: 5.115
Authors: Satoru Sakuma; William C Halliday; Ruka Nomura; Shiro Baba; Yosuke Sato; Kazuo Okanari; Midori Nakajima; Elysa Widjaja; Cyrus Boelman; Ayako Ochi; O Carter Snead; James T Rutka; James Drake; Steven Miller; Hiroshi Otsubo Journal: Epilepsia Date: 2016-11-08 Impact factor: 5.864
Authors: Koji Iida; Hiroshi Otsubo; Ismail S Mohamed; Chiyuki Okuda; Ayako Ochi; Shelly K Weiss; Sylvester H Chuang; O Carter Snead Journal: Epilepsia Date: 2005-09 Impact factor: 5.864
Authors: Ingmar Blümcke; Maria Thom; Eleonora Aronica; Dawna D Armstrong; Harry V Vinters; Andre Palmini; Thomas S Jacques; Giuliano Avanzini; A James Barkovich; Giorgio Battaglia; Albert Becker; Carlos Cepeda; Fernando Cendes; Nadia Colombo; Peter Crino; J Helen Cross; Olivier Delalande; François Dubeau; John Duncan; Renzo Guerrini; Philippe Kahane; Gary Mathern; Imad Najm; Ciğdem Ozkara; Charles Raybaud; Alfonso Represa; Steven N Roper; Noriko Salamon; Andreas Schulze-Bonhage; Laura Tassi; Annamaria Vezzani; Roberto Spreafico Journal: Epilepsia Date: 2010-11-10 Impact factor: 5.864
Authors: Johannes Schurr; Roland Coras; Karl Rössler; Tom Pieper; Manfred Kudernatsch; Hans Holthausen; Peter Winkler; Friedrich Woermann; Christian G Bien; Tilman Polster; Reinhard Schulz; Thilo Kalbhenn; Horst Urbach; Albert Becker; Thomas Grunwald; Hans-Juergen Huppertz; Antonio Gil-Nagel; Rafael Toledano; Martha Feucht; Angelika Mühlebner; Thomas Czech; Ingmar Blümcke Journal: Brain Pathol Date: 2016-02-22 Impact factor: 6.508
Authors: Imad Najm; Dennis Lal; Mario Alonso Vanegas; Fernando Cendes; Iscia Lopes-Cendes; Andre Palmini; Eliseu Paglioli; Harvey B Sarnat; Christopher A Walsh; Samuel Wiebe; Eleonora Aronica; Stéphanie Baulac; Roland Coras; Katja Kobow; J Helen Cross; Rita Garbelli; Hans Holthausen; Karl Rössler; Maria Thom; Assam El-Osta; Jeong Ho Lee; Hajime Miyata; Renzo Guerrini; Yue-Shan Piao; Dong Zhou; Ingmar Blümcke Journal: Epilepsia Date: 2022-06-15 Impact factor: 6.740
Authors: Mariasavina Severino; Ana Filipa Geraldo; Norbert Utz; Domenico Tortora; Ivana Pogledic; Wlodzimierz Klonowski; Fabio Triulzi; Filippo Arrigoni; Kshitij Mankad; Richard J Leventer; Grazia M S Mancini; James A Barkovich; Maarten H Lequin; Andrea Rossi Journal: Brain Date: 2020-10-01 Impact factor: 13.501