A-M Grapperon1, M Berro2, E Salort-Campana2, A Verschueren2, E Delmont3, S Attarian4. 1. Referral Center for Neuromuscular Diseases and ALS, AP-HM, Timone University Hospital, 13385 Marseille, France. Electronic address: aude-marie.grapperon@ap-hm.fr. 2. Referral Center for Neuromuscular Diseases and ALS, AP-HM, Timone University Hospital, 13385 Marseille, France. 3. Referral Center for Neuromuscular Diseases and ALS, AP-HM, Timone University Hospital, 13385 Marseille, France; CNR2M, CNRS UMR 7286, Aix-Marseille University, 13005 Marseille, France. 4. Referral Center for Neuromuscular Diseases and ALS, AP-HM, Timone University Hospital, 13385 Marseille, France; INSERM UMR S 910, Aix-Marseille University, 13005 Marseille, France.
Abstract
INTRODUCTION: A retrospective analysis was performed to document the clinical and electrophysiological features of Guillain-Barré syndrome (GBS) subtypes using different diagnostic criteria. METHODS: One hundred GBS patients were included. Clinical and laboratory features were analyzed, and patients were classified according to four sets of diagnostic criteria. Electrodiagnostic criteria were also analyzed. RESULTS: A total of 69 patients met Asbury and Cornblath's criteria, 96 met Van der Meché's criteria, 99 met Wakerley's diagnostic classification and 86 met level 1 or 2 of the Brighton criteria. Rates of GBS subtypes were: 69% classic GBS; 8% Miller-Fisher syndrome; 12% paraparetic GBS; 2% pharyngeal-cervical-brachial GBS; and 9% unclassified. Those for electrodiagnostic subtypes were 52% demyelinating and 9% axonal according to Hadden's criteria vs 41% demyelinating and 41% axonal as per Rajabally's criteria. CONCLUSION: In this study of case distribution within the GBS spectrum of a retrospective cohort of French patients, the application of new diagnostic criteria enabled accurate diagnoses and classifications of the different subtypes, and also increased the recognition of axonal GBS.
INTRODUCTION: A retrospective analysis was performed to document the clinical and electrophysiological features of Guillain-Barré syndrome (GBS) subtypes using different diagnostic criteria. METHODS: One hundred GBS patients were included. Clinical and laboratory features were analyzed, and patients were classified according to four sets of diagnostic criteria. Electrodiagnostic criteria were also analyzed. RESULTS: A total of 69 patients met Asbury and Cornblath's criteria, 96 met Van der Meché's criteria, 99 met Wakerley's diagnostic classification and 86 met level 1 or 2 of the Brighton criteria. Rates of GBS subtypes were: 69% classic GBS; 8% Miller-Fisher syndrome; 12% paraparetic GBS; 2% pharyngeal-cervical-brachial GBS; and 9% unclassified. Those for electrodiagnostic subtypes were 52% demyelinating and 9% axonal according to Hadden's criteria vs 41% demyelinating and 41% axonal as per Rajabally's criteria. CONCLUSION: In this study of case distribution within the GBS spectrum of a retrospective cohort of French patients, the application of new diagnostic criteria enabled accurate diagnoses and classifications of the different subtypes, and also increased the recognition of axonal GBS.
Authors: Luíza Morais de Matos; Ariely Teotonio Borges; Aline Barbosa Palmeira; Vinicius Moreira Lima; Ernane Pires Maciel; Rubens Nelson Morato Fernandez; João Pedro Lima Mendes; Gustavo Adolfo Sierra Romero Journal: Rev Soc Bras Med Trop Date: 2022-04-08 Impact factor: 2.141