María Bettina Ortiz-Medina1,2, Marta Perea3,4, Julio Torales2,5, Antonio Ventriglio6, Giovanna Vitrani6, Lourdes Aguilar7,8, Carlos Roncero3,7,8. 1. 1 Area of Research, Department of Medical Psychology, Faculty of Medical Sciences, National University Asuncion, San Lorenzo, Paraguay. 2. 2 Hospital de Clínicas, Faculty of Medical Sciences, National University of Asuncion, San Lorenzo, Paraguay. 3. 3 Addiction and Dual Diagnosis Unit, Department of Psychiatry, Vall d'Hebron University Hospital, Public Health Agency of Barcelona (ASPB), CIBERSAM, Barcelona, Spain. 4. 4 Department of Psychiatry and Legal Medicine, Autonomous University of Barcelona, Bellaterra, Spain. 5. 5 Department of Psychiatry, Faculty of Medical Sciences, National University of Asuncion, San Lorenzo, Paraguay. 6. 6 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. 7. 7 Psychiatric Service, University of Salamanca Health Care Complex, Salamanca, Spain. 8. 8 Institute of Biomedicine of Salamanca, University of Salamanca, Salamanca, Spain.
Abstract
OBJECTIVE: : Cannabis consumption produces psychopathology, in some cases psychotic episodes, which are of our interest in this work. However, the relationship between cannabis use and psychosis has not been fully elucidated. The objectives of this work are to (1) review the current state of knowledge on the association of cannabis use with the risk of the development of psychosis or psychotic symptoms in people without schizophrenia and (2) assess the consistency of the hypothesis that cannabis use is associated with increased risk of psychosis in people without schizophrenia. METHOD: : This work included research done in humans until May 2018 with the keywords 'cannabis' and 'psychosis', published in English and Spanish, in the PubMed database. RESULTS: : In all, 66 papers were analyzed, of which 23 were cohort trials and 43 were reviews. CONCLUSION: : Cannabis use doubles the risk of developing psychosis in vulnerable people. There even exists a relationship regarding the dose used and the age of first use. Gene-environment interactions that modulate the association between cannabis use and the presence of psychosis have also been described.
OBJECTIVE: : Cannabis consumption produces psychopathology, in some cases psychotic episodes, which are of our interest in this work. However, the relationship between cannabis use and psychosis has not been fully elucidated. The objectives of this work are to (1) review the current state of knowledge on the association of cannabis use with the risk of the development of psychosis or psychotic symptoms in people without schizophrenia and (2) assess the consistency of the hypothesis that cannabis use is associated with increased risk of psychosis in people without schizophrenia. METHOD: : This work included research done in humans until May 2018 with the keywords 'cannabis' and 'psychosis', published in English and Spanish, in the PubMed database. RESULTS: : In all, 66 papers were analyzed, of which 23 were cohort trials and 43 were reviews. CONCLUSION: : Cannabis use doubles the risk of developing psychosis in vulnerable people. There even exists a relationship regarding the dose used and the age of first use. Gene-environment interactions that modulate the association between cannabis use and the presence of psychosis have also been described.
Authors: Valerio Ricci; Giovanni Martinotti; Franca Ceci; Stefania Chiappini; Francesco Di Carlo; Julius Burkauskas; Ottavia Susini; Debora Luciani; Diego Quattrone; Domenico De Berardis; Mauro Pettorruso; Giuseppe Maina; Massimo Di Giannantonio Journal: Int J Environ Res Public Health Date: 2021-11-30 Impact factor: 3.390