Reliability of Short-Term Heart Rate Variability Indexes Assessed through Photoplethysmography.

The gold standard method to monitor heart rate variability (HRV) comprises measuring the time series of interbeat interval durations from electrocardiographic (ECG) recordings. However, due to the widespread use, simplicity and usability of photoplethysmographic (PPG) techniques, monitoring pulse rate variability (PRV) from pulse wave recordings has become a viable alternative to standard HRV analysis. The present study investigates the accuracy of PRV, measured as a surrogate of HRV, for the quantification of descriptive indexes computed in the time domain (mean, variance), frequency domain (low-to-high frequency power ratio LF/HF, HF band central frequency) and information domain (entropy, conditional entropy). We analyze short time series (300 intervals) of HRV measured from the ECG and of PRV acquired from Finometer device in 76 subjects monitored in the resting supine position (SU) and in the upright position during head-up tilt (HUT). Time, frequency and information domain indexes are computed for each HRV and PRV series and, for each index, the comparison between the two approaches is performed through statistical comparison of the distributions across subjects, robust linear regression, and Bland-Altman plots. Results of the comparison indicate an overall good agreement between PRV-based and HRV-based indexes, with an accuracy that is slightly lower during HUT than during SU, and for the band-power ratio and conditional entropy. These results suggest the feasibility of PRV-based assessment of HRV descriptive indexes, and suggest to further investigate the agreement in conditions of physiological stress.