Analysis of Spontaneous EEG Activity in Alzheimer's Disease Using Weighted Visibility Graph.

This study was aimed at characterizing spontaneous electroencephalography (EEG) activity in Alzheimer's disease (AD) using a novel approach named weighted visibility graph (WVG). More than 10 minutes of spontaneous EEG were recorded from 15 AD patients and 15 age-matched normal controls. Two graph metrics, clustering coefficient and average weighted degree, are extracted in different frequency bands for each EEG channel based on the WVG methodology. Furthermore, statistical analysis was performed in different bands and channels for both groups. It is demonstrated that AD patients are characterized with a significant increase of clustering coefficient and degree in theta band, which can be observed in most brain regions. Our results suggest that the WVG method can be are effective to distinguish different brain states (AD and normal) and may provide further insights into the underlying brain dynamics in AD.