Ketil Oppedal1, Daniel Ferreira2, Lena Cavallin3, Afina W Lemstra4, Mara Ten Kate4, Alessandro Padovani5, Irena Rektorova6, Laura Bonanni7, Lars-Olof Wahlund2, Knut Engedal8, Flavio Nobili9, Milica Kramberger10, John-Paul Taylor11, Jakub Hort12, Jon Snædal13, Frederic Blanc14, Zuzana Walker15, Angelo Antonini16, Eric Westman17, Dag Aarsland18. 1. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Department of Radiology, Stavanger University Hospital, Stavanger, Norway. 2. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 3. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Radiology, Karolinska University Hospital, Stockholm, Sweden. 4. Department of Neurology and Alzheimercenter, VU Universisty Medical Center, Amsterdam, Netherlands. 5. Neurology Unit, Department o Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. 6. 1(st) Department of Neurology, Medical Faculty, St. Anne's Hospital and CEITEC, Masaryk University, Brno, Czech Republic. 7. Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy. 8. Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust and Oslo University Hospital, Oslo, Norway. 9. Department of Neuroscience (DINOGMI), University of Genoa and Neurology Clinics, Polyclinic San Martino Hospital, Genoa, Italy. 10. Department of Neurology, University Medical Centre Ljubljana, Medical faculty, University of Ljubljana, Slovenia. 11. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom. 12. Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. 13. Landspitali University Hospital, Reykjavik, Iceland. 14. Day Hospital of Geriatrics, Memory Resource and Research Centre (CM2R) of Strasbourg, Department of Geriatrics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and French National Centre for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Intégrative en Santé (IMIS)/ICONE, Strasbourg, France. 15. University College London, London & Essex Partnership University NHS Foundation Trust, United Kingdom. 16. Department of Neuroscience, University of Padua, Padua & Fondazione Ospedale San Camillo, Venezia, Venice, Italy. 17. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 18. Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: daarsland@gmail.com.
Abstract
INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS:Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
Authors: Alifiya Kapasi; Jared R Brosch; Kelly N Nudelman; Sonal Agrawal; Tatiana M Foroud; Julie A Schneider Journal: Neuropathology Date: 2020-08-12 Impact factor: 1.906
Authors: Daniel Ferreira; Scott A Przybelski; Timothy G Lesnick; Afina W Lemstra; Elisabet Londos; Frederic Blanc; Zuzana Nedelska; Christopher G Schwarz; Jonathan Graff-Radford; Matthew L Senjem; Julie A Fields; David S Knopman; Rodolfo Savica; Tanis J Ferman; Neill R Graff-Radford; Val J Lowe; Clifford R Jack; Ronald C Petersen; Brit Mollenhauer; Sara Garcia-Ptacek; Carla Abdelnour; Jakub Hort; Laura Bonanni; Ketil Oppedal; Milica G Kramberger; Bradley F Boeve; Dag Aarsland; Eric Westman; Kejal Kantarci Journal: Neurology Date: 2020-09-28 Impact factor: 9.910
Authors: Daniel Ferreira; Zuzana Nedelska; Jonathan Graff-Radford; Scott A Przybelski; Timothy G Lesnick; Christopher G Schwarz; Hugo Botha; Matthew L Senjem; Julie A Fields; David S Knopman; Rodolfo Savica; Tanis J Ferman; Neill R Graff-Radford; Val J Lowe; Clifford R Jack; Ronald C Petersen; Afina W Lemstra; Marleen van de Beek; Frederik Barkhof; Frederic Blanc; Paulo Loureiro de Sousa; Nathalie Philippi; Benjamin Cretin; Catherine Demuynck; Jakub Hort; Ketil Oppedal; Bradley F Boeve; Dag Aarsland; Eric Westman; Kejal Kantarci Journal: Neurobiol Aging Date: 2021-05-14 Impact factor: 5.133