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Literature DB >> 3043665

Mammalian glucocorticoid receptor derivatives enhance transcription in yeast.

Abstract

In mammalian cells, the glucocorticoid receptor binds specifically to glucocorticoid response element (GRE) DNA sequences and enhances transcription from linked promoters. It is shown here that derivatives of the glucocorticoid receptor also enhance transcription when expressed in yeast. Receptor-mediated enhancement in yeast was observed in fusions of GRE sequences to the yeast cytochrome c1 (CYC1) promoter; the CYC1 upstream activator sequences were not essential, since enhancement was observed in fusions of GREs to mutant CYC1 promoters retaining only the TATA region and transcription startpoints. It is concluded that the receptor operates by a common, highly conserved mechanism in yeast and mammalian cells.

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Year: 1988 PMID： 3043665 DOI： 10.1126/science.3043665

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

104 in total

1. The coactivator dTAF(II)110/hTAF(II)135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB.

Authors: E A Felinski; P G Quinn
Journal: Proc Natl Acad Sci U S A Date: 2001-10-30 Impact factor: 11.205

2. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo.

Authors: Daniel L Riggs; Patricia J Roberts; Samantha C Chirillo; Joyce Cheung-Flynn; Viravan Prapapanich; Thomas Ratajczak; Richard Gaber; Didier Picard; David F Smith
Journal: EMBO J Date: 2003-03-03 Impact factor: 11.598

3. Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.

Authors: K Czaplinski; N Majlesi; T Banerjee; S W Peltz
Journal: RNA Date: 2000-05 Impact factor: 4.942

Mammalian glucocorticoid receptor derivatives enhance transcription in yeast.

1. The coactivator dTAF(II)110/hTAF(II)135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB.

2. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo.

3. Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.

4. Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast.

5. Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.

6. Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro.

7. Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.

8. Identification of C. elegans DAF-12-binding sites, response elements, and target genes.

9. Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1).

10. Phytochrome assembly in living cells of the yeast Saccharomyces cerevisiae.