Literature DB >> 30431033

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics.

Julia Revuelta1, Roberto Fuentes, Laura Lagartera, María José Hernáiz, Agatha Bastida, Eduardo García-Junceda, Alfonso Fernández-Mayoralas.   

Abstract

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.

Entities:  

Year:  2018        PMID： 30431033     DOI： 10.1039/c8cc08067d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of their Biological Functions.

Authors:  Giulia Vessella; José Antonio Vázquez; Jesús Valcárcel; Laura Lagartera; Dianélis T Monterrey; Agatha Bastida; Eduardo García-Junceda; Emiliano Bedini; Alfonso Fernández-Mayoralas; Julia Revuelta
Journal:  Polymers (Basel)       Date:  2021-01-19       Impact factor: 4.329

2.  Assembly of a Library of Pel-Oligosaccharides Featuring α-Glucosamine and α-Galactosamine Linkages.

Authors:  Yongzhen Zhang; Liming Wang; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
Journal:  Front Chem       Date:  2022-01-26       Impact factor: 5.221
  2 in total

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