Electrospun bimetallic Au-Ag/Co3O4 nanofibers for sensitive detection of hydrogen peroxide released from human cancer cells.

Bimetallic Au-Ag/Co3O4 nanofibers (Au-Ag/Co3O4NFs) were synthesized by an electrospinning method and calcination treatment. Due to the admirable synergic effect of electrocatalytic ability of Au and Ag, and the large surface-to-volume ratio of Co3O4 nanofibers caused by their rough surface, the synthesized Au-Ag/Co3O4NFs were applied to a sensing platform for hydrogen peroxide oxidation. Using electrochemical techniques, the novel sensing platform based on Au-Ag/Co3O4NFs shows a wide linear concentration range with high detection sensitivity of 1241.1 μA mM-1 cm-2. This sensitive sensor was also applied to determine H2O2 from human breast cancer cells, indicating its great potential application in physiology and pathology.