Yuhang Jia1, Hongbo Zhang1, Shengbing Yang2, Zhenhao Xi3, Tingting Tang2, Ruixue Yin1, Wenjun Zhang4. 1. School of Mechanical & Power Engineering, Complex and Intelligent Systems Research Centre, East China University of Science & Technology, Shanghai 200237, China. 2. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. 3. School of Chemical Engineering, East China University of Science & Technology, Shanghai 200237, China. 4. Division of Biomedical Engineering, University of Saskatchewan, Saskatoon SK S7N 5A2, Canada.
Abstract
AIM: To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs). MATERIALS & METHODS: PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out. RESULTS: The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process. CONCLUSION: PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability.
AIM: To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs). MATERIALS & METHODS: PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out. RESULTS: The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process. CONCLUSION: PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability.
Authors: Alan Saúl Álvarez-Suárez; Syed G Dastager; Nina Bogdanchikova; Daniel Grande; Alexey Pestryakov; Juan Carlos García-Ramos; Graciela Lizeth Pérez-González; Karla Juárez-Moreno; Yanis Toledano-Magaña; Elena Smolentseva; Juan Antonio Paz-González; Tatiana Popova; Lyubov Rachkovskaya; Vadim Nimaev; Anastasia Kotlyarova; Maksim Korolev; Andrey Letyagin; Luis Jesús Villarreal-Gómez Journal: Micromachines (Basel) Date: 2020-04-22 Impact factor: 2.891