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Literature DB >> 3042761

Is efficiency of suppressor tRNAs controlled at the level of ribosomal proofreading in vivo?

Abstract

Ribosomal rpsD mutations did not stimulate nonsense suppressor tRNAs in a general manner according to their increased ribosomal ambiguity and decreased proofreading efficiency. Streptomycin, which stimulates error production by blocking proofreading in vitro, did not increase efficiency of suppressor tRNAs in strains with normal or streptomycin-resistant (rpsL) ribosomes. It did so only in combination with one rpsL mutation which is associated with streptomycin pseudodependence.

Entities: Chemical

Mesh：

Substances：

Year: 1988 PMID： 3042761 PMCID： PMC211358 DOI： 10.1128/jb.170.8.3756-3760.1988

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

31 in total

1. Culture medium for enterobacteria.

Authors: F C Neidhardt; P L Bloch; D F Smith
Journal: J Bacteriol Date: 1974-09 Impact factor: 3.490

2. A semi-quantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli. Evaluation of some molecular parameters of translation in vivo.

Authors: J Ninio
Journal: J Mol Biol Date: 1974-04-05 Impact factor: 5.469

6. Bacteriophage T7 morphogenesis and gene 10 frameshifting in Escherichia coli showing different degrees of ribosomal fidelity.

Authors: J Sipley; J Dunn; E Goldman
Journal: Mol Gen Genet Date: 1991-12

6 in total

Is efficiency of suppressor tRNAs controlled at the level of ribosomal proofreading in vivo?

1. Culture medium for enterobacteria.

2. A semi-quantitative treatment of missense and nonsense suppression in the strA and ram ribosomal mutants of Escherichia coli. Evaluation of some molecular parameters of translation in vivo.

3. Restriction, de-restriction and mistranslation in missense suppression. Ribosomal discrimination of transfer RNA's.

4. Tryptophan transfer RNA as the UGA suppressor.

5. Role modifications in tyrosine transfer RNA: a modified base affecting ribosome binding.

6. A ribosomal ambiguity mutation.

7. Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA.

8. Effects of miaA on translation and growth rates.

9. Ribosomal discrimination of tRNAs.

10. Alteration of a 30S ribosomal protein accompanying the ram mutation in Escherichia coli.

1. Variable surface protein Vmm of Mycoplasma mycoides subsp. mycoides small colony type.

2. Quantitative analysis of in vivo ribosomal events at UGA and UAG stop codons.

Review 3. Errors and alternatives in reading the universal genetic code.

4. Aminoglycoside suppression at UAG, UAA and UGA codons in Escherichia coli and human tissue culture cells.

5. Increased ribosomal accuracy increases a programmed translational frameshift in Escherichia coli.

6. Bacteriophage T7 morphogenesis and gene 10 frameshifting in Escherichia coli showing different degrees of ribosomal fidelity.