James John1, Rosemol Varghese1, Jones Lionell1, Ayyanraj Neeravi1, Balaji Veeraraghavan2. 1. Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. 2. Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Correspondence to: Dr Balaji Veeraraghavan, Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India. vbalaji@cmcvellore.ac.in.
Abstract
OBJECTIVE: To report the percentage of non-vaccine pneumococcal serotypes and their antibiotic susceptibility pattern in children with invasive peumococcal disease. METHODS: Invasive pneumococcal isolates of children <5 years during January 2007 to December 2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerase chain reaction. RESULTS: Among the total 170 S. pneumoniae invasive isolates, 54 (31.8%) and 44 (25.9%) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%) and all isolates were susceptible to cefotaxime. CONCLUSIONS: One-fourth to one-third of the S. pneumoniae serotypes in under-five children with invasive pneumococcal disease are not covered by existing pneumococcal vaccines in India.
OBJECTIVE: To report the percentage of non-vaccine pneumococcal serotypes and their antibiotic susceptibility pattern in children with invasive peumococcal disease. METHODS: Invasive pneumococcal isolates of children <5 years during January 2007 to December 2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerase chain reaction. RESULTS: Among the total 170 S. pneumoniae invasive isolates, 54 (31.8%) and 44 (25.9%) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%) and all isolates were susceptible to cefotaxime. CONCLUSIONS: One-fourth to one-third of the S. pneumoniae serotypes in under-five children with invasive pneumococcal disease are not covered by existing pneumococcal vaccines in India.
Authors: Geetha Nagaraj; Vandana Govindan; Feroze Ganaie; V T Venkatesha; Paulina A Hawkins; Rebecca A Gladstone; Lesley McGee; Robert F Breiman; Stephen D Bentley; Keith P Klugman; Stephanie W Lo; K L Ravikumar Journal: Microb Genom Date: 2021-09