Literature DB >> 30426843

RNA Therapeutics for Tissue Engineering.

Elizabeth R Balmayor1,2, Christopher H Evans2.   

Abstract

RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. Not only is it unstable and difficult to deliver across hydrophobic cell membranes, but extraneous RNA also activates innate immune nucleic acid sensors, which makes it toxic and inflammatory.

Keywords:  DNA/RNA delivery; RNA interference; enabling technologies in tissue engineering; mesenchymal stem cells; messenger RNA; microRNA; small interfering RNA

Mesh：

Substances：

Year:  2019        PMID： 30426843     DOI： 10.1089/ten.TEA.2018.0315

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  5 in total

Review 1.  Gene therapy for bone healing: lessons learned and new approaches.

Authors:  Rodolfo E De la Vega; Aysegul Atasoy-Zeybek; Joseph A Panos; Martijn VAN Griensven; Christopher H Evans; Elizabeth R Balmayor
Journal:  Transl Res       Date:  2021-05-05       Impact factor: 10.171

Review 2.  The biological applications of DNA nanomaterials: current challenges and future directions.

Authors:  Wenjuan Ma; Yuxi Zhan; Yuxin Zhang; Chenchen Mao; Xueping Xie; Yunfeng Lin
Journal:  Signal Transduct Target Ther       Date:  2021-10-08

3.  Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2.

Authors:  Rodolfo E De La Vega; Martijn van Griensven; Wen Zhang; Michael J Coenen; Christopher V Nagelli; Joseph A Panos; Carlos J Peniche Silva; Johannes Geiger; Christian Plank; Christopher H Evans; Elizabeth R Balmayor
Journal:  Sci Adv       Date:  2022-02-16       Impact factor: 14.136

Review 4.  Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.

Authors:  Rachael S Watson-Levings; Glyn D Palmer; Padraic P Levings; E Anthony Dacanay; Christopher H Evans; Steven C Ghivizzani
Journal:  Front Bioeng Biotechnol       Date:  2022-06-28

5.  Modulating myoblast differentiation with RNA-based controllers.

Authors:  Peter B Dykstra; Thomas A Rando; Christina D Smolke
Journal:  PLoS One       Date:  2022-09-27       Impact factor: 3.752
  5 in total

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