Matteo Bassetti1, Luigia Scudeller2, Daniele R Giacobbe3,4, Frederic Lamoth5,6, Elda Righi1, Valentina Zuccaro2, Cecilia Grecchi2, Chiara Rebuffi2, Murat Akova7, Ana Alastruey-Izquierdo8, Sevtap Arikan-Akdagli9, Elie Azoulay10, Stijn I Blot11, Oliver A Cornely12, Cornelia Lass-Flörl13, Philipp Koehler12, Manuel Cuenca-Estrella8, Dylan W de Lange14, Francesco G De Rosa15, Jan J De Waele16, George Dimopoulos17, José Garnacho-Montero18, Martin Hoenigl19,20, Souha S Kanj21, Johan Maertens22, Ignacio Martin-Loeches23, Patricia Muñoz24,25, Bart J Kullberg26, Christina Agvald-Ohman27, Garyphallia Poulakou28, Jordi Rello29, Maurizio Sanguinetti30, Fabio S Taccone31, Jean-François Timsit32,33, Antoni Torres34, Jose A Vazquez35, Thierry Calandra5. 1. Infectious Diseases Clinic, Department of Medicine, University of Udine and Santa Maria Misericordia Hospital, Udine, Italy. 2. Scientific Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 3. Clinica Malattie Infettive, Ospedale Policlinico San Martino - IRCCS per l'Oncologia, Genoa, Italy. 4. Department of Health Sciences, University of Genoa, Genoa, Italy. 5. Infectious Diseases Service, Department of Medicine, Lausanne University, Lausanne, Switzerland. 6. Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland. 7. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University Ankara, Ankara, Turkey. 8. Spanish Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain. 9. Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. 10. AP-HP, Saint-Louis Hospital, Medical Intensive Care Unit, Paris (LZ, EA), ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 INSERM, Paris Diderot, Sorbonne University, Paris, France. 11. Department of Internal Medicine, Faculty of Medicine & Health Science, Ghent University, Ghent, Belgium. 12. Department I of Internal Medicine, University Hospital of Cologne and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany. 13. Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria. 14. Department of Intensive Care, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands. 15. Department of Medical Sciences, University of Turin, Turin, Italy. 16. Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium. 17. Department of Critical Care, University Hospital Attikon, Medical School, University of Athens, Athens, Greece. 18. Unidad Clínica de Cuidados Intensivos, Hospital Universitario Virgen Macarena and Institute of Biomedicine of Seville, IBiS/CSIC/University of Seville, Seville, Spain. 19. Division of Infectious Diseases, Department of Medicine, University of California-San Diego, San Diego, California. 20. Section of Infectious Diseases and Tropical Medicine and Division of Pulmonology, Medical University of Graz, Graz, Austria. 21. Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. 22. Hematology, Department of Immunology and biology, KU Leuven, Leuven, Belgium. 23. Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland. 24. Department of Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 25. Instituto de Investigación Sanitaria Gregorio Marañón, CIBERES, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. 26. Department of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands. 27. Department of Clinical Science, Intervention and Technology, Division of Anaesthesiology and Intensive Care, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. 28. 3rd Department of Medicine, Medical School, Sotiria General Hospital, National and Kapodistrian University of Athens, Athens, Greece. 29. CIBERES, Universitat Autonoma de Barcelona, Barcelona, Spain. 30. Institute of Microbiology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy. 31. Department of Intensive Care, CUB - Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium. 32. Université Paris Diderot/Hopital Bichat-Réanimation Medicale et Des Maladies Infectieuses, Paris, France. 33. UMR 1137-IAME Team 5-DeSCID: Decision Sciences in Infectious Diseases, Control and Care, Inserm/Univ Paris Diderot, Sorbonne Paris Cité, Paris, France. 34. Department of Pulmonary Medicine, Hospital Clinic of Barcelona, University of Barcelona, CIBERES, IDIBAPS, Barcelona, Spain. 35. Department of Medicine, Division of Infectious Diseases, Medical College of Georgia/Georgia Regents University, Augusta, Georgia.
Abstract
BACKGROUND: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). OBJECTIVES: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. METHODS: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. CONCLUSIONS: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.
BACKGROUND: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). OBJECTIVES: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. METHODS: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically IllPatients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. CONCLUSIONS: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.
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Authors: J Peter Donnelly; Sharon C Chen; Carol A Kauffman; William J Steinbach; John W Baddley; Paul E Verweij; Cornelius J Clancy; John R Wingard; Shawn R Lockhart; Andreas H Groll; Tania C Sorrell; Matteo Bassetti; Hamdi Akan; Barbara D Alexander; David Andes; Elie Azoulay; Ralf Bialek; Robert W Bradsher; Stephane Bretagne; Thierry Calandra; Angela M Caliendo; Elio Castagnola; Mario Cruciani; Manuel Cuenca-Estrella; Catherine F Decker; Sujal R Desai; Brian Fisher; Thomas Harrison; Claus Peter Heussel; Henrik E Jensen; Christopher C Kibbler; Dimitrios P Kontoyiannis; Bart-Jan Kullberg; Katrien Lagrou; Frédéric Lamoth; Thomas Lehrnbecher; Jurgen Loeffler; Olivier Lortholary; Johan Maertens; Oscar Marchetti; Kieren A Marr; Henry Masur; Jacques F Meis; C Orla Morrisey; Marcio Nucci; Luis Ostrosky-Zeichner; Livio Pagano; Thomas F Patterson; John R Perfect; Zdenek Racil; Emmanuel Roilides; Marcus Ruhnke; Cornelia Schaefer Prokop; Shmuel Shoham; Monica A Slavin; David A Stevens; George R Thompson; Jose A Vazquez; Claudio Viscoli; Thomas J Walsh; Adilia Warris; L Joseph Wheat; P Lewis White; Theoklis E Zaoutis; Peter G Pappas Journal: Clin Infect Dis Date: 2020-09-12 Impact factor: 9.079
Authors: Ines Schroeder; Karl Dichtl; Uwe Liebchen; Johannes Wagener; Michael Irlbeck; Michael Zoller; Christina Scharf Journal: Infection Date: 2020-09-03 Impact factor: 3.553
Authors: Philipp Koehler; Oliver A Cornely; Bernd W Böttiger; Fabian Dusse; Dennis A Eichenauer; Frieder Fuchs; Michael Hallek; Norma Jung; Florian Klein; Thorsten Persigehl; Jan Rybniker; Matthias Kochanek; Boris Böll; Alexander Shimabukuro-Vornhagen Journal: Mycoses Date: 2020-05-15 Impact factor: 4.377