A Cu(II)-anchored unzipped covalent triazine framework with peroxidase-mimicking properties for molecular imprinting-based electrochemiluminescent detection of sulfaquinoxaline.

The authors describe a method of electrochemiluminescent quantitation of the antibiotic sulfaquinoxaline (SQX). It relies on the use of a molecularly imprinted polymer and a Cu(II)-anchored unzipped covalent triazine framework (UnZ-CCTF) with excellent dispersibility, electrical conductivity, and peroxidaze-like activity. The framework was prepared by unzipping a covalent triazine framework under retention of basic triazine units. It was morphologically and structurally characterized by a range of instrumental techniques. The excellent peroxidase-mimicking effect of UnZ-CCTF on the electrochemiluminescence of the luminol/H2O2 system was exploited to design an ultrasensitive SQX assay with a 1.0-20 pM detection range and a detection limit of 0.76 pM (at 3δ/m). The technique was used for SQX quantitation in spiked milk samples, achieving recoveries of 94.0-104.8%. Graphical abstract Scheme of the sulfaquinoxaline molecularly imprinted electrochemiluminescence sensor based on Cu-anchored unzipped covalent triazine frameworks.