Literature DB >> 3042462

Involvement of proteasomes (multicatalytic proteinase) in ATP-dependent proteolysis in rat reticulocyte extracts.

K Tanaka1, A Ichihara.   

Abstract

The role of proteasomes, particles with latent multicatalytic proteinase, in ATP-dependent proteolysis in rat reticulocyte extracts was examined. Removal of proteasomes from the extracts by immunoprecipitation caused almost complete inhibition of ATP-dependent degradation of [3H]methylcasein, without affecting ATP-dependent proteolysis. Peptide fragments of [3H]casein, obtained by cyanogen bromide cleavage, were rapidly degraded in an ATP-independent fashion and this activity was not affected by removal of the proteasomes. These results suggest that proteasomes are involved in ATP-dependent proteolysis in the extracts and that they catalyze the initial cleavage of large proteins.

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Year:  1988        PMID： 3042462     DOI： 10.1016/0014-5793(88)80306-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex.

Authors:  J Driscoll; J Frydman; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

2.  ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

Authors:  E Eytan; D Ganoth; T Armon; A Hershko
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

3.  Abnormally high expression of proteasomes in human leukemic cells.

Authors:  A Kumatori; K Tanaka; N Inamura; S Sone; T Ogura; T Matsumoto; T Tachikawa; S Shin; A Ichihara
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

4.  Involvement of the proteasome in various degradative processes in mammalian cells.

Authors:  W Matthews; J Driscoll; K Tanaka; A Ichihara; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

5.  Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin.

Authors:  J Driscoll; A L Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

Review 6.  Inhibitors of the immunoproteasome: current status and future directions.

Authors:  Zachary Miller; Lin Ao; Kyung Bo Kim; Wooin Lee
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

7.  Molecular interaction of the proteasome (multicatalytic proteinase). Evidence that the proteasome is not a constituent of the '26 S' multienzyme complex.

Authors:  A Seelig; P M Kloetzel; L Kuehn; B Dahlmann
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

8.  Degradation of Intrinsically Disordered Proteins by the NADH 26S Proteasome.

Authors:  Peter Tsvetkov; Nadav Myers; Julia Adler; Yosef Shaul
Journal:  Biomolecules       Date:  2020-12-07
  8 in total

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