Silvia Clausi1, Michela Lupo2, Giusy Olivito3, Libera Siciliano4, Maria Pia Contento5, Fabio Aloise6, Luigi Pizzamiglio7, Marco Molinari8, Maria Leggio3. 1. Ataxia Lab, Fondazione Santa Lucia IRCCS, Rome, Italy; Department of Psychology, Sapienza University of Rome, Italy. Electronic address: s.clausi@hsantalucia.it. 2. Ataxia Lab, Fondazione Santa Lucia IRCCS, Rome, Italy. 3. Ataxia Lab, Fondazione Santa Lucia IRCCS, Rome, Italy; Department of Psychology, Sapienza University of Rome, Italy. 4. PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Italy. 5. Centro Sinapsi, Cerignola, Italy. 6. Alfameg s.r.l., Rome, Italy. 7. Department of Psychology, Sapienza University of Rome, Italy; Neuropsychology Lab, Fondazione Santa Lucia IRCCS, Rome, Italy. 8. Robotic Neurorehabilitation Lab, Fondazione Santa Lucia IRCCS, Rome, Italy.
Abstract
BACKGROUND: Although depressive symptoms are often reported to be comorbid with degenerative cerebellar diseases, the role of the cerebellum in depressive disorder needs to be elucidated. To address this aim, we investigated self-perception of the negative mood state in patients with cerebellar pathology and depressive symptoms. METHODS: Thirty-eight patients with cerebellar damage (10 with depressive symptoms - CB-DP and 28 with no depressive symptoms - CB-nDP), 11 subjects with depressive disorders without cerebellar damage (DP) and 29 healthy controls (CTs) were enrolled. A device for self-monitoring of the mood state (MoMo) and validated scales such as the Profile of Mood States questionnaire (POMS), the Self-Report Symptom Inventory-Revised (SCL-90-R) and the Hamilton Depression Rating Scale (HDRS) were used to evaluate depressive symptoms. RESULTS: Both CB-DP and DP patients showed higher scores than CTs on the POMS and SCL-90-R for depressive factors and on the HDRS. DP patients showed a lower frequency of 'good' mood and a higher frequency of 'bad' mood than CTs when using the MoMo device. However, although the two depressed populations showed comparable scores on these validated scales, CB-DP patients showed impaired self-awareness of the mood experience in 'the here and now', as evidenced by the absence of significant differences, compared with CTs, in the subjective mood evaluation performed with the MoMo device. LIMITATIONS: The number of CB patients and inhomogeneity across MRI scans were study limitations. CONCLUSION: Cerebellar dysfunction might slow the data integration necessary for mood state awareness, resulting in difficulty of depressed CB patients in explicitly recognizing their mood "in the here and now".
BACKGROUND: Although depressive symptoms are often reported to be comorbid with degenerative cerebellar diseases, the role of the cerebellum in depressive disorder needs to be elucidated. To address this aim, we investigated self-perception of the negative mood state in patients with cerebellar pathology and depressive symptoms. METHODS: Thirty-eight patients with cerebellar damage (10 with depressive symptoms - CB-DP and 28 with no depressive symptoms - CB-nDP), 11 subjects with depressive disorders without cerebellar damage (DP) and 29 healthy controls (CTs) were enrolled. A device for self-monitoring of the mood state (MoMo) and validated scales such as the Profile of Mood States questionnaire (POMS), the Self-Report Symptom Inventory-Revised (SCL-90-R) and the Hamilton Depression Rating Scale (HDRS) were used to evaluate depressive symptoms. RESULTS: Both CB-DP and DPpatients showed higher scores than CTs on the POMS and SCL-90-R for depressive factors and on the HDRS. DPpatients showed a lower frequency of 'good' mood and a higher frequency of 'bad' mood than CTs when using the MoMo device. However, although the two depressed populations showed comparable scores on these validated scales, CB-DPpatients showed impaired self-awareness of the mood experience in 'the here and now', as evidenced by the absence of significant differences, compared with CTs, in the subjective mood evaluation performed with the MoMo device. LIMITATIONS: The number of CB patients and inhomogeneity across MRI scans were study limitations. CONCLUSION:Cerebellar dysfunction might slow the data integration necessary for mood state awareness, resulting in difficulty of depressed CBpatients in explicitly recognizing their mood "in the here and now".
Authors: Giusy Olivito; L Siciliano; S Clausi; M Lupo; S Romano; M Masciullo; M Molinari; M Cercignani; M Bozzali; M Leggio Journal: Cerebellum Date: 2020-04 Impact factor: 3.847
Authors: Sharif I Kronemer; Mitchell B Slapik; Jessica R Pietrowski; Michael J Margron; Owen P Morgan; Catherine C Bakker; Liana S Rosenthal; Chiadi U Onyike; Cherie L Marvel Journal: Cerebellum Date: 2020-09-30 Impact factor: 3.648