Hyo Geun Choi1, Joo-Hee Kim2, Ji-Young Park3, Yong Il Hwang3, Seung Hun Jang3, Ki-Suck Jung3. 1. Departments of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. 2. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. Electronic address: luxjhee@gmail.com. 3. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Abstract
BACKGROUND: Patients with asthma often suffer from depression and vice versa. However, the temporal relationship between the 2 diseases has remained elusive. OBJECTIVE: The aim of this study was to determine the bidirectional relationship between asthma and depression in adults, using national cohort samples in Korea. METHODS: Using the national cohort from the study by the Korean Health Insurance Review and Assessment Service, patients with asthma and control participants were selected and matched by age group, sex, income group, region of residence, and medical histories. A stratified Cox proportional hazards model was used to analyze the hazard ratio (HR) of asthma with depression (study 1) and depression with asthma (study 2). RESULTS: In study 1, the HR of depressive disorders was significantly higher in patients with asthma than in patients without asthma (HR, 1.35; 95% CI, 1.31-1.40). In study 2, the HR of asthma in patients with depression was significantly higher than that in patients without depression (HR, 1.25; 95% CI, 1.21-1.29). CONCLUSION: A bidirectional association between asthma and depression was observed in this study.
BACKGROUND:Patients with asthma often suffer from depression and vice versa. However, the temporal relationship between the 2 diseases has remained elusive. OBJECTIVE: The aim of this study was to determine the bidirectional relationship between asthma and depression in adults, using national cohort samples in Korea. METHODS: Using the national cohort from the study by the Korean Health Insurance Review and Assessment Service, patients with asthma and control participants were selected and matched by age group, sex, income group, region of residence, and medical histories. A stratified Cox proportional hazards model was used to analyze the hazard ratio (HR) of asthma with depression (study 1) and depression with asthma (study 2). RESULTS: In study 1, the HR of depressive disorders was significantly higher in patients with asthma than in patients without asthma (HR, 1.35; 95% CI, 1.31-1.40). In study 2, the HR of asthma in patients with depression was significantly higher than that in patients without depression (HR, 1.25; 95% CI, 1.21-1.29). CONCLUSION: A bidirectional association between asthma and depression was observed in this study.
Authors: Han Wang; Wei-Jing Kan; Yuan Feng; Lei Feng; Yang Yang; Pei Chen; Jing-Jie Xu; Tian-Mei Si; Ling Zhang; Gang Wang; Jing Du Journal: World J Psychiatry Date: 2021-12-19
Authors: Xiaoqin Liu; Trine Munk-Olsen; Clara Albiñana; Bjarni J Vilhjálmsson; Emil M Pedersen; Vivi Schlünssen; Marie Bækvad-Hansen; Jonas Bybjerg-Grauholm; Merete Nordentoft; Anders D Børglum; Thomas Werge; David M Hougaard; Preben B Mortensen; Esben Agerbo Journal: Brain Behav Immun Date: 2020-07-28 Impact factor: 7.217