| Literature DB >> 30423291 |
Boaz Nachmias1, Aaron D Schimmer2.
Abstract
In this issue of Cancer Cell, Jones et al. demonstrate that LSCs are metabolically inflexible. LSCs rely on amino acid metabolism to fuel oxidative phosphorylation and cannot compensate with other fuel sources following amino acid depletion. Combined venetoclax and azacitidine reduces amino acid uptake, partly explaining the anti-LSC effects.Entities:
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Year: 2018 PMID： 30423291 DOI： 10.1016/j.ccell.2018.10.012
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743