Literature DB >> 30422130

RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS.

Arun K Ghosh1, John Cappiello1, Dongwoo Shin1.   

Abstract

Ring-closing olefin metathesis of acrylates derived from allylic and homo allylic alcohols in the presence of the Grubbs' catalyst (10-15 mol%) and titanium isopropoxide (0.3-3 equiv) provided ready access to α, β-unsaturated γ- and δ-lactones and an important dipeptide isostere intermediate.

Entities:  

Year:  1998        PMID： 30422130      PMCID： PMC6223311          DOI： 10.1016/S0040-4039(98)00887-9

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  7 in total

1.  Conformationally Unbiased Macrocyclization Reactions by Ring Closing Metathesis.

Authors:  Alois Fürstner; Klaus Langemann
Journal:  J Org Chem       Date:  1996-06-14       Impact factor: 4.354

2.  Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy.

Authors:  Arun K Ghosh; Khaja Azhar Hussain
Journal:  Tetrahedron Lett       Date:  1998-04-02       Impact factor: 2.415

3.  Asymmetric Aldol-Ring-Closing Metathesis Strategy for the Enantioselective Construction of Six- to Nine-Membered Oxygen Heterocycles.

Authors:  Michael T Crimmins; Allison L Choy
Journal:  J Org Chem       Date:  1997-10-31       Impact factor: 4.354

4.  Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic.

Authors:  Arun K Ghosh; Sean P McKee; Wayne J Thompson; Paul L Darke; Joan C Zugay
Journal:  J Org Chem       Date:  1993-02       Impact factor: 4.354

5.  An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

Authors:  P Ashorn; T J McQuade; S Thaisrivongs; A G Tomasselli; W G Tarpley; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

6.  Synthesis of epothilones A and B in solid and solution phase.

Authors:  K C Nicolaou; N Winssinger; J Pastor; S Ninkovic; F Sarabia; Y He; D Vourloumis; Z Yang; T Li; P Giannakakou; E Hamel
Journal:  Nature       Date:  1997-05-15       Impact factor: 49.962

7.  3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.

Authors:  A K Ghosh; W J Thompson; S P McKee; T T Duong; T A Lyle; J C Chen; P L Darke; J A Zugay; E A Emini; W A Schleif
Journal:  J Med Chem       Date:  1993-01-22       Impact factor: 7.446
  7 in total
  2 in total

Review 1.  Reactions of Allylmagnesium Reagents with Carbonyl Compounds and Compounds with C═N Double Bonds: Their Diastereoselectivities Generally Cannot Be Analyzed Using the Felkin-Anh and Chelation-Control Models.

Authors:  Nicole D Bartolo; Jacquelyne A Read; Elizabeth M Valentín; K A Woerpel
Journal:  Chem Rev       Date:  2020-01-06       Impact factor: 60.622

2.  Synthesis of a library of tricyclic azepinoisoindolinones.

Authors:  Bettina Miller; Shuli Mao; Kara M George Rosenker; Joshua G Pierce; Peter Wipf
Journal:  Beilstein J Org Chem       Date:  2012-07-13       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.